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TY - GEN
ID - cogprints6211
UR - http://cogprints.org/6211/
A1 - DiPirro, Jean M.
A1 - Thompson, Alexis C.
A1 - Kristal, Dr. Mark B.
Y1 - 1991///
N2 - Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.
PB - Pergamon Press
KW - POEF
KW - analgesia
KW - pain
KW - rats
KW - morphine
KW - opioids
KW - placenta
KW - quaternary naltrexone
KW - amniotic fluid
KW - placentophagia
KW - naltrexone methobromide
TI - Amniotic-Fluid Ingestion Enhances the Central
Analgesic Effect of Morphine
SP - 851
AV - public
EP - 855
ER -