creators_name: DiPirro, Jean M.
creators_name: Thompson, Alexis C.
creators_name: Kristal, Mark B.
creators_id: dipirrjm@buffalostate.edu
creators_id: athompso@ria.buffalo.edu
creators_id: kristal@buffalo.edu
type: journalp
datestamp: 2008-09-19 13:55:05
lastmod: 2011-03-11 08:57:12
metadata_visibility: show
title: Amniotic-Fluid Ingestion Enhances the Central
Analgesic Effect of Morphine
ispublished: pub
subjects: psy-bio
subjects: physio-psy
subjects: neuro-pharm
subjects: behav-neuro-sci
full_text_status: public
keywords: POEF, analgesia, pain, rats, morphine, opioids, placenta, quaternary naltrexone, amniotic fluid, placentophagia, naltrexone methobromide
abstract: Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.
date: 1991
date_type: published
publication: Brain Research Bulletin
volume: 26
number: 6
publisher: Pergamon Press
pagerange: 851-855
refereed: TRUE
citation:   DiPirro, Jean M. and Thompson, Alexis C. and Kristal, Dr. Mark B.  (1991) Amniotic-Fluid Ingestion Enhances the Central Analgesic Effect of Morphine.  [Journal (Paginated)]     
document_url: http://cogprints.org/6211/1/central.pdf