---
abstract: 'Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.'
altloc: []
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
- dipirrjm@buffalostate.edu
- athompso@ria.buffalo.edu
- kristal@buffalo.edu
creators_name:
- family: DiPirro
given: Jean M.
honourific: ''
lineage: ''
- family: Thompson
given: Alexis C.
honourific: ''
lineage: ''
- family: Kristal
given: Mark B.
honourific: Dr.
lineage: ''
date: 1991
date_type: published
datestamp: 2008-09-19 13:55:05
department: ~
dir: disk0/00/00/62/11
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editors_id: []
editors_name: []
eprint_status: archive
eprintid: 6211
fileinfo: /style/images/fileicons/application_pdf.png;/6211/1/central.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'POEF, analgesia, pain, rats, morphine, opioids, placenta, quaternary naltrexone, amniotic fluid, placentophagia, naltrexone methobromide'
lastmod: 2011-03-11 08:57:12
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 6
pagerange: 851-855
pubdom: TRUE
publication: Brain Research Bulletin
publisher: Pergamon Press
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 29
series: ~
source: ~
status_changed: 2008-09-19 13:55:05
subjects:
- psy-bio
- physio-psy
- neuro-pharm
- behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: "Amniotic-Fluid Ingestion Enhances the Central\r\nAnalgesic Effect of Morphine"
type: journalp
userid: 88
volume: 26