?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Dose-Dependent+Enhancement+of+Morphine-Induced+Analgesia%0D%0Aby+Ingestion+of+Amniotic+Fluid+and+Placenta&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.creator=Abbott%2C+Patricia&rft.creator=Thompson%2C+Alexis+C.&rft.subject=Behavioral+Biology&rft.subject=Psychobiology&rft.subject=Physiological+Psychology&rft.subject=Comparative+Psychology&rft.subject=Animal+Behavior&rft.subject=Behavioral+Neuroscience&rft.subject=Neurochemistry&rft.description=Ingestion+of+amniotic+fluid+and+placenta+by+rats+has+been+shown+to+enhance+opioid-mediated+analgesia.+The+present+studies+were+designed+to+examine+the+effect+of+several+doses+and+volumes+of+placenta+and+amniotic+fluid+on+tail-flick+latency+in+rats+treated+with+3+mg%2Fkg+morphine.+The+optimal+dose+of+amniotic+fluid+was+found+to+be+0.25+ml%2C+although+0.50+and+1.0+ml+also+produced+significant+enhancement.+Doses+of+0.125+and+2+ml+of+amniotic+fluid+were+ineffective%2C+as+was+a+dose+of+0.25+ml+diluted+to+2+ml+with+saline.+The+optimal+dose+of+placenta+was+found+to+be+1+placenta%2C+although+the+resulting+enhancement+was+not+significantly+greater+than+that+produced+by+0.25%2C+0.50%2C+2.0+or+4.0+placentas.+Doses+smaller+than+0.25+placenta+or+larger+than+4.0+placentas+were+ineffective.+The+most+effective+doses+of+amniotic+fluid+and+placenta+correspond+to+the+amounts+delivered+with+each+pup+during+parturition.&rft.publisher=Pergamon+Press&rft.date=1988&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6220%2F1%2Fdose.pdf&rft.identifier=++Kristal%2C+Dr.+Mark+B.+and+Abbott%2C+Patricia+and+Thompson%2C+Alexis+C.++(1988)+Dose-Dependent+Enhancement+of+Morphine-Induced+Analgesia+by+Ingestion+of+Amniotic+Fluid+and+Placenta.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6220%2F