?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Blockade+of+Digestion+by+Famotidine%0D%0APretreatment+Does+Not+Interfere+With+the+Opioid-Enhancing%0D%0AEffect+of+Ingested+Amniotic+Fluid&rft.creator=Robinson%2C+T.M.&rft.creator=Abbott%2C+Patricia&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Psychobiology&rft.subject=Physiological+Psychology&rft.subject=Behavioral+Neuroscience&rft.description=Ingestion+of+placenta+or+amniotic+fluid+by+rats+has+been+shown+to+enhance+ongoing+opioid-mediated+antinociception%2C+but+does+not%2C+by+itself%2C+produce+antinociception.+This+enhancement+is+produced+by+an+active+substance(s)+in+placenta+and+amniotic+fluid+that+we+have+termed+POEF+for+placental+opioid-enhancing+factor.+Previous+research+has+shown+that+enhancement+requires+mediation+by+the+gastrointestinal+system%3A+gastric+vagotomy+blocks+enhancement+produced+by+ingested+placenta%3B+amniotic+fluid+injected+SC+or+IP+does+not+produce+enhancement.+The+present+study+was+designed+to+distinguish+between+two+possible+explanations+for+the+blockade+of+the+POEF+effect+produced+by+gastric+vagotomy%3A+that+afferent+information+arising+in+vagal+gastric+receptors+conveys+the+critical+information+to+the+CNS%2C+or+that+disruption+of+vagal+efferent+action+on+digestion+blocks+the+manufacture+or+activation+of+the+POEF+molecule+in+the+gut.+Famotidine+is+an+H2-histamine+receptor+antagonist+that+reduces+gastric+acid+and+pepsin+secretion+to+an+extent+at+least+as+great+as+gastric+vagotomy.+Rats+treated+with+either+famotidine+or+a+vehicle+were+fed+placenta+or+a+control+substance%2C+then+stimulated+with+vaginal%2Fcervical+probing+to+produce+antinociception+that+is+partly+opioid+mediated.+Famotidine+did+not+block+POEF+enhancement+of+vaginal%2Fcervical+stimulation-induced+analgesia+in+a+tail+flick+latency+test.+These+results+suggest+that+enhancement+by+POEF+does+not+require+normal+digestive+processes+or+other+processes+inhibited+by+famotidine.&rft.publisher=Pergamon&rft.date=1995&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6246%2F1%2Ffamotidine.pdf&rft.identifier=++Robinson%2C+T.M.+and+Abbott%2C+Patricia+and+Kristal%2C+Dr.+Mark+B.++(1995)+Blockade+of+Digestion+by+Famotidine+Pretreatment+Does+Not+Interfere+With+the+Opioid-Enhancing+Effect+of+Ingested+Amniotic+Fluid.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6246%2F