?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Ingested+bovine+amniotic+fluid+enhances+morphine+antinociception+in+rats&rft.creator=Corpening%2C+James+W.&rft.creator=Doerr%2C+Jean+C.&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Behavioral+Biology&rft.subject=Psychobiology&rft.subject=Physiological+Psychology&rft.subject=Animal+Behavior&rft.subject=Behavioral+Neuroscience&rft.subject=Neurochemistry&rft.description=Ingestion+by+rats+of+rat+placenta+or+amniotic+fluid+enhances+opioid-mediated%2C+or+partly+opioid-mediated%2C+antinociception+produced+by+morphine+injection%2C+vaginal+or+cervical+stimulation%2C+late+pregnancy%2C+and+foot+shock.+This+phenomenon+is+believed+to+be+produced+by+a+placental%0D%0Aopioid-enhancing+factor+(POEF).+Ingestion+by+rats+of+human+or+dolphin+placenta+has+also+been+shown+to+enhance+opioid+antinociception%2C+suggesting+that+POEF+may+be+common+to+many+mammalian+species.+We+tested+bovine+amniotic+fluid+(BAF)+for+its+capacity+to+enhance+morphine+antinociception+in+female+Long-Evans+rats%2C+as+determined+by+percentage+change+from+baseline+tail-flick+latency+in+response+to+radiant+heat%2C+and+we+report+that+0.50+mL+BAF+effectively+enhanced+morphine+antinociception+but+did+not+by+itself+produce+antinociception.+The+efficacy+of+POEF+across+species+suggests+that+POEF+may+have+been+functionally+(and+structurally)+conserved+during+evolution.+Furthermore%2C+the+availability+of+POEF+at+parturition%2C+as+well+as+its+ability+to+enhance+pregnancy-mediated+antinociception+without%0D%0Adisrupting+maternal+behavior%2C+offers+a+tenable+explanation+for+the+long-debated+ultimate+causality+of+placentophagia.&rft.publisher=Elsevier&rft.date=2000&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6250%2F1%2Fbovine.pdf&rft.identifier=++Corpening%2C+James+W.+and+Doerr%2C+Jean+C.+and+Kristal%2C+Dr.+Mark+B.++(2000)+Ingested+bovine+amniotic+fluid+enhances+morphine+antinociception+in+rats.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6250%2F