---
abstract: 'Dietary fish oil has been shown to inhibit bone resorption and, therefore, the aim of the present study was to test the hypothesis that fish oil alters lipopolysaccharide (LPS)-induced hydroxyapatite loss in rat alveolar bone. Rats were divided into four groups. The animals injected with saline or Escherichia coli-derived LPS into the maxillary alveolar mucosa on the buccoapical site of the molar region daily for 8 days were served as a negative or positive control, respectively. Other groups of animals were injected with LPS and orally treated with fish oil at the same day with or after LPS injection. The results of the present study showed that the hydroxyapatite contents of alveolar bone in rats treated with fish oil at the same day with or before LPS injection were significantly higher than those in rats injected with LPS alone, but still lower than those in untreated animals. Therefore, the present study suggests that oral treatment with fish oil may reduce LPS-induced hydroxyapatite loss in rat alveolar bone'
altloc:
  - http://www.ojhas.org/issue28/2008-4-7.htm
chapter: ~
commentary: ~
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contact_email: ~
creators_id:
  - ~
  - ~
  - ~
  - ~
  - wsosroseno@yahoo.com
creators_name:
  - family: Indahyani
    given: Didin E
    honourific: ''
    lineage: ''
  - family: Santoso
    given: AL Supartinah
    honourific: ''
    lineage: ''
  - family: Utoro
    given: Totok
    honourific: ''
    lineage: ''
  - family: Soesatyo
    given: Marsetyawan HNE
    honourific: ''
    lineage: ''
  - family: Sosroseno
    given: Wihaskoro
    honourific: ''
    lineage: ''
date: 2009-02-25
date_type: published
datestamp: 2009-03-28 09:31:25
department: ~
dir: disk0/00/00/63/94
edit_lock_since: ~
edit_lock_until: ~
edit_lock_user: ~
editors_id:
  - Kakkilaya BS
editors_name:
  - family: Kakkilaya
    given: Srinivas
    honourific: Dr.
    lineage: ''
eprint_status: archive
eprintid: 6394
fileinfo: /style/images/fileicons/application_pdf.png;/6394/1/2008%2D4%2D7.pdf
full_text_status: public
importid: ~
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isbn: ~
ispublished: pub
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item_issues_comment: []
item_issues_count: 0
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item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
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keywords: 'Alveolar, Bone, Fish Oil, Hydroxyapatite, Rat'
lastmod: 2011-03-11 08:57:20
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 4
pagerange: ~
pubdom: TRUE
publication: Online Journal of Health And Allied Sciences
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
referencetext: "1.Watkins BA, Li Y, Seifert MF. Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology. J Am Coll Nutr. 2001;20:410S-6S.\r\n2.Indahyani DE, Pudyani PS, Santoso ALS, et al. The effect of fish oil on bone resorption following pulp exposure in rats. Dent Traumatol. 2002;28:206-11.\r\n3.Kesavalu L, Vasudevan B, Raghu B, et al. Omega-3 fatty acid effect on alveolar bone loss in rats. J Dent Res. 2006;85:648-52.\r\n4.Iwami-Morimoto I, Yamaguchi K, Tanne K. Influence of dietary n-3 polyunsaturated fatty acid on experimental tooth movement in rats. Angle Orthod. 1999;69:365-71.\r\n5.Arnett TR. Extracellular pH regulates bone cell function. J Nutr. 2008;138:415S-8S.\r\n6.Jonarta AL, Pudyani PS, Sosroseno W. Effect of high-density lipoprotein on lipopolysaccharide-induced alveolar bone resorption in rats. Oral Dis 2002;8:261-7.\r\n7.Vardar-Sengül S, Buduneli N, Buduneli E, et al. Dietary supplementation of omega-3 fatty acid and circulating levels of interleukin-1β, osteocalcin, and C-reactive protein in rats. J Periodontol 2006;77:814-20. \r\n8.Watkins BA, Li Y, Lippman HE, Feng S. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism. Prostaglandins Leukot Essent Fatty Acids 2003;68:387-98."
relation_type: []
relation_uri: []
reportno: ~
rev_number: 21
series: ~
source: ~
status_changed: 2009-03-28 09:31:25
subjects:
  - OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: A Preliminary Study'
type: journale
userid: 4338
volume: 7
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