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<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats"^^ . "We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under isoflurane anesthesia), sham surgery (anesthesia only), or neither and were treated postoperatively with 1 of several doses of subcutaneous buprenorphine. Pain sensitivity to noxious and nonnoxious mechanical stimuli at the site of injury (primary pain) was assessed at 1, 4, 24, and 72 h after surgery. Pain sensitivity at a site distal to the injury (secondary pain) was assessed at 24 and 72 h after surgery. Rats were tested for their sensitivity to the analgesic and\r\nlocomotor effects of morphine 9 to 10 d after surgery. Buprenorphine at 0.05 mg/kg SC was determined to be the most effective; this dose induced isoalgesia during the acute postoperative period and the longest period of pain relief, and it did not induce longterm changes in opioid sensitivity in 2 functional measures of the opioid system. A lower dose of buprenorphine (0.01 mg/kg SC) did not meet the criterion for isoalgesia, and a higher dose (0.1 mg/kg SC) was less effective in pain relief at later recovery periods and induced a long-lasting opioid tolerance, indicating greater neural adaptations. These results support the use of 0.05 mg/kg SC buprenorphine as the upper dose limit for effective treatment of postoperative pain in rats and suggest that higher doses produce long-term effects on opioid sensitivity."^^ . "2009" . . "59" . "1" . . "American Association for Laboratory Animal Science"^^ . . . "Comparative Medicine"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . "Mark B."^^ . "Kristal"^^ . "Mark B. Kristal"^^ . . "Lisa B.E."^^ . "Martin"^^ . "Lisa B.E. Martin"^^ . . "Mauricio"^^ . "Suarez"^^ . "Mauricio Suarez"^^ . . "Julie A."^^ . "Grakowsky"^^ . "Julie A. Grakowsky"^^ . . "Jean M."^^ . "DiPirro"^^ . "Jean M. DiPirro"^^ . . "Leslie I."^^ . "Curtin"^^ . "Leslie I. Curtin"^^ . . "Alexis C."^^ . "Thompson"^^ . "Alexis C. Thompson"^^ . . . . . . "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats (PDF)"^^ . . . . . . . . . . . "s7.pdf"^^ . . . "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #6399 \n\nEvaluation of Buprenorphine in a Postoperative \nPain Model in Rats\n\n" . "text/html" . . . "Psychobiology" . . . "Physiological Psychology" . . . "Neuropharmacology" . . . "Behavioral Neuroscience" . .