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"Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats"^^ .
"We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under isoflurane anesthesia), sham surgery (anesthesia only), or neither and were treated postoperatively with 1 of several doses of subcutaneous buprenorphine. Pain sensitivity to noxious and nonnoxious mechanical stimuli at the site of injury (primary pain) was assessed at 1, 4, 24, and 72 h after surgery. Pain sensitivity at a site distal to the injury (secondary pain) was assessed at 24 and 72 h after surgery. Rats were tested for their sensitivity to the analgesic and\r\nlocomotor effects of morphine 9 to 10 d after surgery. Buprenorphine at 0.05 mg/kg SC was determined to be the most effective; this dose induced isoalgesia during the acute postoperative period and the longest period of pain relief, and it did not induce longterm changes in opioid sensitivity in 2 functional measures of the opioid system. A lower dose of buprenorphine (0.01 mg/kg SC) did not meet the criterion for isoalgesia, and a higher dose (0.1 mg/kg SC) was less effective in pain relief at later recovery periods and induced a long-lasting opioid tolerance, indicating greater neural adaptations. These results support the use of 0.05 mg/kg SC buprenorphine as the upper dose limit for effective treatment of postoperative pain in rats and suggest that higher doses produce long-term effects on opioid sensitivity."^^ .
"2009" .
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"59" .
"1" .
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"American Association for Laboratory Animal Science"^^ .
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"Comparative Medicine"^^ .
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"Mark B."^^ .
"Kristal"^^ .
"Mark B. Kristal"^^ .
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"Lisa B.E."^^ .
"Martin"^^ .
"Lisa B.E. Martin"^^ .
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"Mauricio"^^ .
"Suarez"^^ .
"Mauricio Suarez"^^ .
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"Julie A."^^ .
"Grakowsky"^^ .
"Julie A. Grakowsky"^^ .
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"Jean M."^^ .
"DiPirro"^^ .
"Jean M. DiPirro"^^ .
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"Leslie I."^^ .
"Curtin"^^ .
"Leslie I. Curtin"^^ .
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"Alexis C."^^ .
"Thompson"^^ .
"Alexis C. Thompson"^^ .
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"Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats (PDF)"^^ .
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"s7.pdf"^^ .
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"Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats (Image (PNG))"^^ .