6399 31 4339 5 20562 document 4339 s7.pdf application/pdf 488982 2009-12-08 21:08:50 http://cogprints.org/6399/1/s7.pdf 6399 1 application/pdf application/pdf buprenorphine evaluation en public

s7.pdf

published http://eprints.org/relation/hasVolatileVersion http://cogprints.org/id/document/7295 http://eprints.org/relation/haspreviewThumbnailVersion http://cogprints.org/id/document/7295 http://eprints.org/relation/hasVersion http://cogprints.org/id/document/7295 http://eprints.org/relation/hasVolatileVersion http://cogprints.org/id/document/7594 http://eprints.org/relation/hasVersion http://cogprints.org/id/document/7594 http://eprints.org/relation/hasIndexCodesVersion http://cogprints.org/id/document/7594 archive 88 disk0/00/00/63/99 2009-03-28 09:30:03 2011-03-11 08:57:20 2009-03-28 09:30:03 journalp show 0 We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under isoflurane anesthesia), sham surgery (anesthesia only), or neither and were treated postoperatively with 1 of several doses of subcutaneous buprenorphine. Pain sensitivity to noxious and nonnoxious mechanical stimuli at the site of injury (primary pain) was assessed at 1, 4, 24, and 72 h after surgery. Pain sensitivity at a site distal to the injury (secondary pain) was assessed at 24 and 72 h after surgery. Rats were tested for their sensitivity to the analgesic and locomotor effects of morphine 9 to 10 d after surgery. Buprenorphine at 0.05 mg/kg SC was determined to be the most effective; this dose induced isoalgesia during the acute postoperative period and the longest period of pain relief, and it did not induce longterm changes in opioid sensitivity in 2 functional measures of the opioid system. A lower dose of buprenorphine (0.01 mg/kg SC) did not meet the criterion for isoalgesia, and a higher dose (0.1 mg/kg SC) was less effective in pain relief at later recovery periods and induced a long-lasting opioid tolerance, indicating greater neural adaptations. These results support the use of 0.05 mg/kg SC buprenorphine as the upper dose limit for effective treatment of postoperative pain in rats and suggest that higher doses produce long-term effects on opioid sensitivity. Curtin Leslie I. Dr. licurtin@buffalo.edu Grakowsky Julie A. jg96@buffalo.edu Suarez Mauricio msuarez@ria.buffalo.edu Thompson Alexis C. Dr. athompso@ria.buffalo.edu DiPirro Jean M. Dr. dipirrjm@buffalostate.edu Martin Lisa B.E. Dr. lbmartin@buffalo.edu Kristal Mark B. Dr. kristal@buffalo.edu pub buprenorphine, pain, antinociception, allodynia, postsurgical, opiates, rat, hypoalgesia, isoalgesia, analgesia 1 60-71 FALSE Comparative Medicine American Association for Laboratory Animal Science TRUE psy-bio physio-psy neuro-pharm behav-neuro-sci 59 published 2009 public