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--- abstract: "We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under isoflurane anesthesia), sham surgery (anesthesia only), or neither and were treated postoperatively with 1 of several doses of subcutaneous buprenorphine. Pain sensitivity to noxious and nonnoxious mechanical stimuli at the site of injury (primary pain) was assessed at 1, 4, 24, and 72 h after surgery. Pain sensitivity at a site distal to the injury (secondary pain) was assessed at 24 and 72 h after surgery. Rats were tested for their sensitivity to the analgesic and\r\nlocomotor effects of morphine 9 to 10 d after surgery. Buprenorphine at 0.05 mg/kg SC was determined to be the most effective; this dose induced isoalgesia during the acute postoperative period and the longest period of pain relief, and it did not induce longterm changes in opioid sensitivity in 2 functional measures of the opioid system. A lower dose of buprenorphine (0.01 mg/kg SC) did not meet the criterion for isoalgesia, and a higher dose (0.1 mg/kg SC) was less effective in pain relief at later recovery periods and induced a long-lasting opioid tolerance, indicating greater neural adaptations. These results support the use of 0.05 mg/kg SC buprenorphine as the upper dose limit for effective treatment of postoperative pain in rats and suggest that higher doses produce long-term effects on opioid sensitivity." altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - licurtin@buffalo.edu - jg96@buffalo.edu - msuarez@ria.buffalo.edu - athompso@ria.buffalo.edu - dipirrjm@buffalostate.edu - lbmartin@buffalo.edu - kristal@buffalo.edu creators_name: - family: Curtin given: Leslie I. honourific: Dr. lineage: '' - family: Grakowsky given: Julie A. honourific: '' lineage: '' - family: Suarez given: Mauricio honourific: '' lineage: '' - family: Thompson given: Alexis C. honourific: Dr. lineage: '' - family: DiPirro given: Jean M. honourific: Dr. lineage: '' - family: Martin given: Lisa B.E. honourific: Dr. lineage: '' - family: Kristal given: Mark B. honourific: Dr. lineage: '' date: 2009 date_type: published datestamp: 2009-03-28 09:30:03 department: ~ dir: disk0/00/00/63/99 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 6399 fileinfo: /style/images/fileicons/application_pdf.png;/6399/1/s7.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'buprenorphine, pain, antinociception, allodynia, postsurgical, opiates, rat, hypoalgesia, isoalgesia, analgesia' lastmod: 2011-03-11 08:57:20 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 1 pagerange: 60-71 pubdom: FALSE publication: Comparative Medicine publisher: American Association for Laboratory Animal Science refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 31 series: ~ source: ~ status_changed: 2009-03-28 09:30:03 subjects: - psy-bio - physio-psy - neuro-pharm - behav-neuro-sci succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats" type: journalp userid: 88 volume: 59