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abstract: "We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound hyperalgesia, and the long-term effects of postoperative opioid treatment on subsequent opioid exposure. Rats received surgery (paw incision under isoflurane anesthesia), sham surgery (anesthesia only), or neither and were treated postoperatively with 1 of several doses of subcutaneous buprenorphine. Pain sensitivity to noxious and nonnoxious mechanical stimuli at the site of injury (primary pain) was assessed at 1, 4, 24, and 72 h after surgery. Pain sensitivity at a site distal to the injury (secondary pain) was assessed at 24 and 72 h after surgery. Rats were tested for their sensitivity to the analgesic and\r\nlocomotor effects of morphine 9 to 10 d after surgery. Buprenorphine at 0.05 mg/kg SC was determined to be the most effective; this dose induced isoalgesia during the acute postoperative period and the longest period of pain relief, and it did not induce longterm changes in opioid sensitivity in 2 functional measures of the opioid system. A lower dose of buprenorphine (0.01 mg/kg SC) did not meet the criterion for isoalgesia, and a higher dose (0.1 mg/kg SC) was less effective in pain relief at later recovery periods and induced a long-lasting opioid tolerance, indicating greater neural adaptations. These results support the use of 0.05 mg/kg SC buprenorphine as the upper dose limit for effective treatment of postoperative pain in rats and suggest that higher doses produce long-term effects on opioid sensitivity."
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chapter: ~
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contact_email: ~
creators_id:
- licurtin@buffalo.edu
- jg96@buffalo.edu
- msuarez@ria.buffalo.edu
- athompso@ria.buffalo.edu
- dipirrjm@buffalostate.edu
- lbmartin@buffalo.edu
- kristal@buffalo.edu
creators_name:
- family: Curtin
given: Leslie I.
honourific: Dr.
lineage: ''
- family: Grakowsky
given: Julie A.
honourific: ''
lineage: ''
- family: Suarez
given: Mauricio
honourific: ''
lineage: ''
- family: Thompson
given: Alexis C.
honourific: Dr.
lineage: ''
- family: DiPirro
given: Jean M.
honourific: Dr.
lineage: ''
- family: Martin
given: Lisa B.E.
honourific: Dr.
lineage: ''
- family: Kristal
given: Mark B.
honourific: Dr.
lineage: ''
date: 2009
date_type: published
datestamp: 2009-03-28 09:30:03
department: ~
dir: disk0/00/00/63/99
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eprint_status: archive
eprintid: 6399
fileinfo: /style/images/fileicons/application_pdf.png;/6399/1/s7.pdf
full_text_status: public
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ispublished: pub
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item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'buprenorphine, pain, antinociception, allodynia, postsurgical, opiates, rat, hypoalgesia, isoalgesia, analgesia'
lastmod: 2011-03-11 08:57:20
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 1
pagerange: 60-71
pubdom: FALSE
publication: Comparative Medicine
publisher: American Association for Laboratory Animal Science
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 31
series: ~
source: ~
status_changed: 2009-03-28 09:30:03
subjects:
- psy-bio
- physio-psy
- neuro-pharm
- behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: "Evaluation of Buprenorphine in a Postoperative\r\nPain Model in Rats"
type: journalp
userid: 88
volume: 59