?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Gene+expression+and+its+discontents%3A+Developmental+disorders+as+dysfunctions+of+epigenetic+cognition&rft.creator=Wallace%2C+Rodrick&rft.subject=Theoretical+Biology&rft.description=Reductionist+treatments+of+the+epigenetic+regulation+of+gene+expression+suffer+the+same+mereological+and+sufficiency+fallacies+that+haunt+both+contemporary+systems+biology+and+neural+network+models+of+high+order+cognition.+Shifting+perspective+from+the+massively+parallel+space+of+gene+matrix+interactions+to+the+grammar%2Fsyntax+of+the+time+series+of+developmentally+expressed+phenotypes+using+a+cognitive+paradigm+permits+import+of+techniques+from+statistical+physics+via+the+homology+between+information+source+uncertainty+and+free+energy+density.+This+produces+a+broad+spectrum+of+'coevolutionary'+probability+models+of+development+and+its+pathologies+in+which+epigenetic+regulation+and+the+effects+of+embedding+environment+are+analogous+to+a+tunable+enzyme+catalyst.+A+cognitive+paradigm+naturally+incorporates+memory%2C+leading+directly+to+models+of+epigenetic+inheritance%2C+as+affected+by+environmental+exposures%2C+in+the+largest+sense.+Understanding+gene+expression%2C+development%2C+and+their+dysfunctions+will+require+data+analysis+tools+considerably+more+sophisticated+than+the+present+crop+of+simplistic+models+abducted+from+neural+network+studies+or+stochastic+chemical+reaction+theory.&rft.date=2009-03-31&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6407%2F1%2Fgenedis16.pdf&rft.identifier=++Wallace%2C+Rodrick++(2009)+Gene+expression+and+its+discontents%3A+Developmental+disorders+as+dysfunctions+of+epigenetic+cognition.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6407%2F