TY  - GEN
ID  - cogprints6550
UR  - http://cogprints.org/6550/
A1  - Georgiev, Danko
A1  - Taniura, Hideo
A1  - Kambe, Yuki
A1  - Yoneda, Yukio
Y1  - 2008/10/02/
N2  - Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathological circumstances such as ischemia, NMDARs might have proapoptotic excitotoxic activity. In contrast brain-derived neurotrophic factor (BDNF) signaling via TrkB receptors has been largely considered to promote neuronal differentiation, plasticity and survival during normal development, and protect neurons in pathophysiological conditions antagonizing the NMDAR-mediated excitotoxic cell death. In this review we summarize recent evidence for the existent crosstalk and positive feedback loops between the BDNF and NMDAR signaling and point out some of the important specific features of each signaling pathway.
PB  - Bulgarian Society for Cell Biology
KW  - NMDA receptor
KW  -  BDNF
KW  -  neurotrophins
TI  - Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
SP  - 17
AV  - public
EP  - 27
ER  -

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