?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+cultural+epigenetics+of+psychopathology%3A+The+missing+heritability+of+complex+diseases+found%3F&rft.creator=Wallace%2C+Rodrick&rft.subject=Neural+Modelling&rft.subject=Cognitive+Psychology&rft.subject=Developmental+Psychology&rft.description=We+extend+a+cognitive+paradigm+for+gene+expression+based+on+the+asymptotic+limit+theorems+of+information+theory+to+the+epigenetic+epidemiology+of+mental+disorders.+In+particular%2C+we+recognize+the+fundamental+role+culture+plays+in+human+biology%2C+another+heritage+mechanism+parallel+to%2C+and+interacting+with%2C+the+more+familiar+genetic+and+epigenetic+systems.+We+do+this+via+a+model+through+which+culture+acts+as+another+tunable+epigenetic+catalyst+that+both+directs+developmental+trajectories%2C+and+becomes+convoluted+with+individual+ontology%2C+via+a+mutually-interacting+crosstalk+mediated+by+a+social+interaction+that+is+itself+culturally+driven.+We+call+for+the+incorporation+of+embedding+culture+as+an+essential+component+of+the+epigenetic+regulation+of+human+mental+development+and+its+dysfunctions%2C+bringing+what+is+perhaps+the+central+reality+of+human+biology+into+the+center+of+biological+psychiatry.+Current+US+work+on+gene-environment+interactions+in+psychiatry+must+be+extended+to+a+model+of+gene-environment-culture+interaction+to+avoid+becoming+victim+of+an+extreme+American+individualism+that+threatens+to+create+paradigms+particular+to+that+culture+and+that+are%2C+indeed%2C+peculiar+in+the+context+of+the+world's+cultures.+The+cultural+and+epigenetic+systems+of+heritage+may+well+provide+the+'missing'+heritability+of+complex+diseases+now+under+so+much+intense+discussion.&rft.date=2009-10-14&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6658%2F1%2Fmdis12a.pdf&rft.identifier=++Wallace%2C+Rodrick++(2009)+The+cultural+epigenetics+of+psychopathology%3A+The+missing+heritability+of+complex+diseases+found%3F++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6658%2F