TY  - GEN
ID  - cogprints6664
UR  - http://cogprints.org/6664/
A1  - Mungli, Prakash
A1  - Shetty, Mahesh S
A1  - Tilak, Prasiddha
A1  - Anwar, Naureen
Y1  - 2009/09/08/
N2  - Thiols are the organic compounds that contain a sulphydryl group. Among all the antioxidants that are available in the body, thiols constitute the major portion of the total body antioxidants and they play a significant role in defense against reactive oxygen species. Total thiols composed of both intracellular and extracellular thiols either in the free form as oxidized or reduced glutathione, or thiols bound to proteins. Among the thiols that are bound to proteins, albumin makes the major portion of the protein bound thiols, which binds to sufhydryl group at its cysteine-34 portion. Apart from their role in defense against free radicals, thiols share significant role in detoxification, signal transduction, apoptosis and various other functions at molecular level. The thiol status in the body can be assessed easily by determining the serum levels of thiols. Decreased levels of thiols has been noted in various medical disorders including chronic renal failure and other disorders related to kidney, cardiovascular disorders, stroke and other neurological disorders, diabetes mellitus, alcoholic cirrhosis and various other disorders. Therapy using thiols has been under investigation for certain disorders
PB  - Kakkilaya BS
KW  - Thiols
KW  -  antioxidants
KW  -  glutathione
KW  -  free radicals
KW  -  kidney diseases
KW  -  cysteine-SH
KW  -  ?-glutamyl cycle
TI  - Total Thiols: Biomedical Importance And Their Alteration In Various Disorders
AV  - public
ER  -

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