creators_name: Bist, SS creators_name: Varshney, Saurabh creators_name: Singh, Rakesh Kumar creators_name: Bhagat, Sanjeev creators_name: Gupta, Nitin creators_id: sampanbist@yahoo.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2009-11-14 11:38:07 lastmod: 2011-03-11 08:57:30 metadata_visibility: show title: Primary Non-Hodgkin's Malignant Lymphoma of the Sinonasal Tract ispublished: pub subjects: OJHAS full_text_status: public keywords: Sinonasal lymphoma, Non Hodgkins lymphoma, Immunohistochemistry abstract: Primary non-Hodgkin’s lymphomas (NHL) of the sinonasal tract are rather uncommon entities. Morphologically and radiographically, sinonasal lymphomas are difficult to distinguish from other malignant neoplasms or non- neoplastic processes. They have a variable presentation from fulminant destructive manifestations to chronic indolent type of disease and may mimic as carcinomas and invasive fungal infection respectively. We report a case of primary NHL involving sinonasal tract in elderly female, which was clinically and radiologically mimicking as sinonasal malignany and was proven as NHL on histological examination and confirmed by immunohistochemistry. A high index of suspicion, appropriate histopathological examination and immunohistochemistry is necessary to differentiate sinonasal lymphomas from other possibilities. Failure to do so may miss the diagnosis and delay appropriate treatment date: 2009-09-08 date_type: published publication: Online Journal of Health and Allied Sciences volume: 8 number: 2 publisher: Kakkilaya BS refereed: TRUE referencetext: 1. Shohat I, Berkowicz M, Dori S, Horowitz Z, Wolf M, Taicher S et al. Primary non-Hodgkin’s lymphoma of the sinonasal tract. Oral Surg Oral Med Oral Pathol 2004;97:328-31. 2. Quraishi M, Bessel E, Clark D, Jones N, Bradley P. Non Hodgkin’s lymphoma of the sinonasal tract. Laryngoscope 2000;110:1489-92. 3. Abbondanzo S, Wenig B. Non Hodgkin’s lymphoma of the sinonasal tract. Cancer 1995;75:1281-91. 4. Harris N, Jaffe E, Stein H, Banks P, Chan J, Cleary M et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361-92. 5. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage. The non-Hodgkin’s lymphoma pathologic classification project. Cancer 1982;49:2112-35. 6. Cheung MM, Chan JK, Lau WH, Foo W, Chan PT, Ng CS et al. Primary non-Hodgkin’s lymphoma of the nose and nasopharynx: clinical features,tumor immunophenotype and treatment outcome in 113 patients. J Clin Otol 1998:16:70-7 7. Cleary KC, Batsakis JG. Sinonasal lymphomas. Ann Otol Rhinol Laryngol 1994;103:911-4. 8. Vidal RW, Devaney K, Ferlito A et al. Sinonasal malignant lymphomas: A distinct clinicopathological category. Ann Otol Rhinol Laryngol 1999;108:411-19. 9. Nakamura K, Uehara S, Omagari J, Kunitake N, Kimura M, Makino Y, Ishigami K, Masuda K. Primary non-Hodgkin lymphoma of the sinonasal cavities: correlation of CT evaluation with clinical outcome. Radiology 1997;204:431-435 10. Longsdon M, Ha C, Kavadi V, Cabanillas F, Hess M, Cox J. Lymphoma of the nasal cavity and paranasal sinuses. Improved outcome and altered prognostic factors with combined modality therapy. Cancer 1997;80:477-88. citation: Bist, SS and Varshney, Saurabh and Singh, Rakesh Kumar and Bhagat, Sanjeev and Gupta, Nitin (2009) Primary Non-Hodgkin's Malignant Lymphoma of the Sinonasal Tract. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/6675/1/2009-2-9.pdf