?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Learning+curve+assessment+of+rule+use+provides+evidence+for+spared+implicit+sequence+learning+in+a+mouse+model+of+mental+retardation&rft.creator=Bauchwitz%2C+Dr.+Robert&rft.subject=Comparative+Psychology&rft.description=Humans+with+Fragile+X+Syndrome+(FXS)+have+a+mental+retardation+of+which+a+notable+characteristic+is+a+weakness+in+recalling+sequences+of+information.+A+mouse+model+of+the+disorder+exists+which+exhibits+behavioral+and+neurologic+changes%2C+but+cognitive+testing+has+not+revealed+learning+deficits+seemingly+comparable+in+magnitude+to+that+seen+in+the+human+condition.+A+working+memory+task+for+olfactory+sequences+was+employed+to+test+learning+set+acquisition+in+mice%2C+half+of+which+had+a+disruption+of+the+gene+responsible+for+FXS+in+humans.+The+task+protected+against+reward+detection+artifact+and+demonstrated+stringency-dependent+task+acquisition.+A+comparable+image-based+sequence+learning+set+task+was+used+to+test+humans.+The+performances+of+human+subjects+who+did+and+did+not+report+consciously+acquiring+the+task+rules+were+used+as+positive+and+negative+controls+to+assess+the+mouse+learning+curves.+Learning+curve+plateau+error+fluctuation+for+individual+mice+was+comparable+to+that+of+human+subjects+who+never+acquired+an+explicit+rule+to+perform+the+task%2C+but+different+from+those+of+human+subjects+who+could+state+a+rule+to+solve+the+problem.+Sliding+window+error+plots+and+nonparametric+statistical+analysis+discriminated+between+the+consciously+rule-based+human+performances+and+that+of+the+mice+and+humans+who+did+not+explicitly+obtain+the+rule.+Based+on+comparison+to+the+human+results%2C+wild-type+and+FX+mouse+learning+curves+with+a+continuingly+variable+terminal+plateau+error+rate+in+sliding+epochs+were+classified+as+%E2%80%9Cimplicit%E2%80%9D.+Although+a+moderately+large+difference+in+performance+of+the+olfactory+task+was+observed+among+mouse+strains%2C+there+was+no+significant+effect+of+FX+genotype.+The+wild-type+performance+of+the+FX+mice+in+this+sequence+task+suggests+that+implicit+learning+may+be+relatively+spared+in+FXS.&rft.date=2009-12-23&rft.type=Preprint&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6755%2F1%2FCai2009_manuscript_learning_curves_rule_use_092709.pdf&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6755%2F2%2FFigures_Cai2009_052609.pdf&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6755%2F3%2FSupplemental_Information_Cai2009_0909.pdf&rft.identifier=++Bauchwitz%2C+Dr.+Robert++(2009)+Learning+curve+assessment+of+rule+use+provides+evidence+for+spared+implicit+sequence+learning+in+a+mouse+model+of+mental+retardation.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6755%2F