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--- abstract: 'Ingestion of amniotic fluid or placenta by rats has been shown to enhance opioid-mediated analgesia induced by morphine injection, foot shock, vaginal/cervical stimulation, or late pregnancy. The present study was designed to determine whether this mechanism might be a means of providing greater analgesia during the periparturitional period without contributing to the disruption of maternal behavior (measured primarily as retrieval) that can result from excessive opioid levels. Postpartum primiparous rats, injected with either 2 or 3 mg/kg morphine sulfate or vehicle and given orogastric infusions of either amniotic fluid or saline, were tested for maternal behavior. Pain threshold (determined by tail-flick latency test) in rats injected with 2 mg/kg morphine and infused with amniotic fluid was elevated to a level that did not differ significantly from that of a separate group of rats injected with 3 mg/kg morphine and infused with saline. This enhanced analgesia was not, however, accompanied by the significant disruption of maternal behavior found among the rats receiving the higher morphine dose.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Tarapacki given: J. A. honourific: '' lineage: '' - family: Piech given: M. honourific: '' lineage: '' - family: Kristal given: M. B. honourific: '' lineage: '' date: 1995 date_type: published datestamp: 1998-11-14 department: ~ dir: disk0/00/00/00/68 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 68 fileinfo: /style/images/fileicons/text_html.png;/68/1/piech.htm full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'parturition, POEF, maternal behavior, placentophagia, pain, antinociception, analgesia, amniotic fluid, opioids, morphine, pregnancy, postpartum, tail-flick latency' lastmod: 2011-03-11 08:53:39 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 2 pagerange: 209-212 pubdom: FALSE publication: Physiology & Behavior publisher: ~ refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 8 series: ~ source: ~ status_changed: 2007-09-12 16:22:43 subjects: - behav-neuro-sci - behav-neuro-sci - bio-behav - comp-psy - neuro-chem - neuro-endocrin - neuro-pharm - physio-psy - psy-bio succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Ingestion of amniotic fluid by postpartum rats enhances morphine antinociception without liability to maternal behavior type: journalp userid: 88 volume: 57