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--- abstract: 'Objective: To evaluate the risk factors associated with fatality in mechanically ventilated neonates using multiple regression analysis. Design & settings: Prospective study conducted at Neonatal ICU at New Civil Hospital, Surat – a tertiary care centre, from December, 2007 to May, 2008 for 6 months. Methods: Fifty neonates in NICU consecutively put on mechanical ventilator during study period were enrolled in the study. The pressure limited time cycled ventilator was used. All admitted neonates were subjected to an arterial blood gas analysis along with a set of investigations to look for pulmonary maturity, infections, renal function, hyperbilirubinemia, intraventricular hemorrhage and congenital anomalies. Different investigation facilities were used as and when required during ventilation of neonates. Multiple logistic regression analysis was done to find out the predictors of fatality among these neonates. Results: Various factors suspected as predictors of fatality of mechanically ventilated neonates were assessed. Hypothermia, prolonged capillary refill time (CRT), initial requirement of oxygen fraction (FiO2) >0.6, alveolar to arterial PO2 difference (AaDO2) >250, alveolar to arterial PO2 ratio (a/A) <0.25, & oxygenation index (OI) >10 were found statistically highly significant predictors of mortality among mechanically ventilated neonates. Conclusion: Hypothermia and prolonged capillary refill time were independent predictors of fatality in neonatal mechanical ventilation. Risk of fatality can be identified in mechanically ventilated neonates.' altloc: - http://www.ojhas.org/issue31/2009-3-9.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - ~ - dranakonda@yahoo.com - ~ creators_name: - family: Trivedi given: SS honourific: '' lineage: '' - family: Chudasama given: RK honourific: '' lineage: '' - family: Srivastava given: A honourific: '' lineage: '' date: 2009-11-15 date_type: published datestamp: 2010-09-13 03:56:09 department: ~ dir: disk0/00/00/69/56 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 6956 fileinfo: /style/images/fileicons/application_pdf.png;/6956/1/2009%2D3%2D9.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Mechanical ventilation, Neonates, Hypothermia, Capillary refill time' lastmod: 2011-03-11 08:57:41 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3 pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Dr. BS Kakkilaya refereed: TRUE referencetext: "1.\tPark K. 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Indian J Pediatr 2002;69:15-18.\r\n16.\tHarris TR, Wood BR. Physiologic principles. In: assisted ventilation of the neonate. Eds Goldsmith SP, Karotkin EH. 3rd edn. Philadelphia, WB Sounders, 1996; p 21-68." relation_type: [] relation_uri: [] reportno: ~ rev_number: 19 series: ~ source: ~ status_changed: 2010-09-13 03:56:09 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Study of Early Predictors of Fatality in Mechanically Ventilated Neonates in NICU type: journale userid: 4338 volume: 8