--- abstract: 'Hereditary hemolytic disorders such as hemoglobin disorders, β-thalassemia syndrome, G6PD deficiency, and ABO and Rhesus blood groups are the most common public health problems in India. Community genetic screening provides multifaceted information for finding prevalence, level of health education, preventive strategies such as genetic/marriage counseling to relieve the burden of vulnerable communities. However, such genetic screening studies are scanty in India. This study aims to find the prevalence of inherited hemolytic disorders in Sindhi community, identify the persons for genetic/marriage counseling and to suggest the relevant strategies for prevention and control to the affected families. A cross-sectional random study of 508 persons of Sindhi community belonging to all ages and both sexes was conducted for screening of hemoglobin disorders, G6PD deficiency and ABO and Rhesus (D) blood groups following the standard procedures and techniques from Jabalpur town in Central India. High frequency of β-thalassemia trait (20.5%), Hb D trait (2.2%) and hemoglobin D/β-thalassemia (0.2%), G6PD deficiency (0.8%), and a low prevalence of Rhesus negative (3.0%) blood group was observed in Sindhi community of Jabalpur town in Madhya Pradesh. A case of β-thalassemia major and Hb D-thalassemia were also encountered. Double heterozygosity of Hb D/β-thalassemia showed hypochromic and microcytic red cell morphology with mild anemia. Inherited hemolytic disorders are an important public health challenge in Sindhi community. Preventive genetics program needs to be vigorously taken up to ameliorate the sufferings of at risk communities in India.' altloc: - http://www.ojhas.org/issue32/2009-4-5.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - balgirrs@yahoo.co.in creators_name: - family: Balgir given: RS honourific: '' lineage: '' date: 2010-04-30 date_type: published datestamp: 2010-09-13 03:54:30 department: ~ dir: disk0/00/00/69/73 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 6973 fileinfo: /style/images/fileicons/application_pdf.png;/6973/1/2009%2D4%2D5.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Public health, Blood groups, Hemoglobin disorders, β-thalassemia syndrome, G6PD deficiency, India' lastmod: 2011-03-11 08:57:42 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 4 pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Dr. BS Kakkilaya refereed: TRUE referencetext: "1.\tWeatherall DJ, Clegg JB. 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Internet J Path 2004;3:1-4.\r\n20.\tBalgir RS. Hematological profile of twenty-nine tribal compound cases of hemoglobinopathies and G6PD deficiency in rural Orissa. Indian J Med Sci. 2008;62: 364-373." relation_type: [] relation_uri: [] reportno: ~ rev_number: 19 series: ~ source: ~ status_changed: 2010-09-13 03:54:30 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Inherited hemolytic disorders with high occurrence of b-thalassemia in Sindhi community of Jabalpur town in Madhya Pradesh, India' type: journale userid: 4338 volume: 8