?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+Comparative+Study+Between+Alcoholics+of+Koraga+Community%2C+Alcoholics+of+General+Population+and+Healthy+Controls+for+Antioxidant+Markers+and+Liver+Function+Parameters&rft.creator=Prakash%2C+M&rft.creator=Anwar%2C+N&rft.creator=Tilak%2C+P&rft.creator=Shetty%2C+MS&rft.creator=Prabhu%2C+LS&rft.creator=Kedage%2C+V&rft.creator=Muttigi%2C+MS&rft.creator=Devaramane%2C+V&rft.creator=Bhandary%2C+PV&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Objectives%3A+It+is+well+established+that+long-term+alcohol+consumption+leads+to+liver+cirrhosis+and+other+related+disorders.+Sufficient+work+has+been+done+on+biochemical+markers+of+liver+damage+and+antioxidant+status+of+chronic+alcoholics+in+general+population.+In+the+current+study+chronic+alcoholics+from+a+community+called+Koraga+are+analysed+for+the+same+parameters+in+a+view+to+assess+the+extent+of+liver+damage+as+compared+to+healthy+controls+and+other+alcoholics.+Methods%3A+Serum+and+urine+samples+from+Koraga+alcoholics+(n%3D28)%2C+general+alcoholics+(n%3D30)+and+healthy+controls+(n%3D31)+were+analysed+for+liver+function+parameters+and+antioxidant+markers.+Liver+function+parameters+were+determined+by+automated+analyzer.+Markers+of+antioxidant+status+were+estimated+spectrophotometrically.+The+data+was+analysed+using+SPSS+version+16.0.+Results%3A+There+was+significant+increase+in+serum+AST%2C+serum+ALT%2C+serum+GST+and+urine+GST+in+both+general+and+Koraga+alcoholics+when+compared+to+healthy+controls+(p%3C0.0001).+Serum+ALT%2C+serum+GST+and+urine+GST+activity+was+significantly+higher+in+general+alcoholics+when+compared+to+Koraga++alcoholics+(p%3C0.001).+Serum+and+urine+total+thiol+levels+were+significantly+lower+in+general+alcoholics+when+compared+to+healthy+controls+and+Koraga++alcoholics+(p%3C0.0001).+We+have+observed+no+difference+in+total+thiols+level+between+healthy+controls+and+Koraga+alcoholics%2C+in+fact%2C+there+was+significant+increase+in+urine+total+thiols+level+in+Koraga+alcoholics+compared+to+healthy+controls+(p%3C0.001).+On+Pearson%E2%80%99s+correlation+serum+AST%2C+serum+ALT+correlated+positively+with+serum+and+urine+GST+(p%3C0.0001)+and+negatively+with+serum+total+thiols+(p%3C0.0001).+Serum+GST+correlated+negatively+with+serum+total+thiols+(p%3C0.0001).+Conclusion%3A+Results+of+our+study+possibly+indicate+that+the+extent+of+alcohol+induced+liver+damage+in+Koraga+subjects+is+comparatively+lower+than+general+alcoholics%2C+even+though+the+alcohol+consumption+is+found+to+be+higher+in+them.+There+may+be+some+mechanism+that+is+rendering+them+resistant+to+alcoholic+liver+damage+which+needs+to+be+explored+through+further+studies+at+molecular+level.&rft.publisher=Dr.+BS+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2010-04-30&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6977%2F1%2F2009-4-8.pdf&rft.identifier=++Prakash%2C+M+and+Anwar%2C+N+and+Tilak%2C+P+and+Shetty%2C+MS+and+Prabhu%2C+LS+and+Kedage%2C+V+and+Muttigi%2C+MS+and+Devaramane%2C+V+and+Bhandary%2C+PV++(2010)+A+Comparative+Study+Between+Alcoholics+of+Koraga+Community%2C+Alcoholics+of+General+Population+and+Healthy+Controls+for+Antioxidant+Markers+and+Liver+Function+Parameters.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6977%2F