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@misc{cogprints6978, volume = {9}, number = {3}, month = {October}, author = {Suresh Babu and Jeevan K Shetty and Prakash Mungli}, editor = {Dr Srinivas Kakkilaya}, title = {Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy}, publisher = {Dr. B.S. Kakkilaya}, year = {2010}, journal = {Online Journal of Health and Allied Sciences}, keywords = {MDA; Total thiols; Myocardial infarction; Reperfusion injury}, url = {http://cogprints.org/6978/}, abstract = {Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p{\ensuremath{<}} 0.001) and significant decrease in total thiols (p{\ensuremath{<}}0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p{\ensuremath{<}}0.05) and positively with CK-MB (r = 0.491, p{\ensuremath{<}}0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.} }