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"Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy"^^ .
"Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols."^^ .
"2010-10-15" .
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"Dr. B.S. Kakkilaya"^^ .
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"Online Journal of Health and Allied Sciences"^^ .
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"Jeevan K"^^ .
"Shetty"^^ .
"Jeevan K Shetty"^^ .
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"Srinivas"^^ .
"Kakkilaya"^^ .
"Srinivas Kakkilaya"^^ .
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"Suresh"^^ .
"Babu"^^ .
"Suresh Babu"^^ .
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"Prakash"^^ .
"Mungli"^^ .
"Prakash Mungli"^^ .
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"Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy (PDF)"^^ .
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"2010-3-6.pdf"^^ .
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"Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy (Image (JPEG))"^^ .
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"preview.jpg"^^ .
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"Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy (Indexer Terms)"^^ .
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"indexcodes.txt"^^ .
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"HTML Summary of #6978 \n\nTotal Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy\n\n" .
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"Online Journal of Health and Allied Sciences" .