creators_name: Babu, Suresh
creators_name: Shetty, Jeevan K
creators_name: Mungli, Prakash
creators_id: drjkshetty1978@yahoo.com
creators_id: prakashmungli@yahoo.co.in
editors_name: Kakkilaya, Srinivas
editors_id: Kakkilaya BS
type: journale
datestamp: 2010-11-22 14:20:05
lastmod: 2011-03-11 08:57:42
metadata_visibility: show
title: Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy
ispublished: pub
subjects: OJHAS
full_text_status: public
keywords: MDA; Total thiols; Myocardial infarction; Reperfusion injury
abstract: Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase  in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.
date: 2010-10-15
date_type: published
publication: Online Journal of Health and Allied Sciences
volume: 9
number: 3
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
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citation:   Babu, Suresh and Shetty, Jeevan K and Mungli, Prakash  (2010) Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy.  [Journal (On-line/Unpaginated)]     
document_url: http://cogprints.org/6978/1/2010-3-6.pdf