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--- abstract: 'Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.' altloc: - http://www.ojhas.org/issue35/2010-3-6.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - ~ - drjkshetty1978@yahoo.com - prakashmungli@yahoo.co.in creators_name: - family: Babu given: Suresh honourific: '' lineage: '' - family: Shetty given: Jeevan K honourific: '' lineage: '' - family: Mungli given: Prakash honourific: '' lineage: '' date: 2010-10-15 date_type: published datestamp: 2010-11-22 14:20:05 department: ~ dir: disk0/00/00/69/78 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 6978 fileinfo: /style/images/fileicons/application_pdf.png;/6978/1/2010%2D3%2D6.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: MDA; Total thiols; Myocardial infarction; Reperfusion injury lastmod: 2011-03-11 08:57:42 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3 pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Dr. B.S. 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Biotechnol Biochem. 1997;61:1901-05." relation_type: [] relation_uri: [] reportno: ~ rev_number: 19 series: ~ source: ~ status_changed: 2010-11-22 14:20:05 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy type: journale userid: 4338 volume: 9