creators_name: Reddy, EP creators_name: Reddy, VS creators_name: Chandra Mouli, K creators_name: Rao, PVLNS creators_id: drpebyreddy@yahoo.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2010-09-13 03:54:07 lastmod: 2011-03-11 08:57:42 metadata_visibility: show title: Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function ispublished: pub subjects: OJHAS full_text_status: public keywords: Oxidative stress, Lipid peroxidation, Antioxidants, Stomach cancer abstract: Role of free radicals has been proposed in the pathogenesis of many diseases. Gastric cancer is a common disease worldwide, and leading cause of cancer death in India. Severe oxidative stress produces reactive oxygen species (ROS) and induces uncontrolled lipid peroxidation. Albumin, uric acid (UA) and Bilirubin are important physiological antioxidants. We aimed to evaluate and assess the role of oxidative stress (OS) and physiological antioxidant system in stomach cancer patients. Lipid peroxidation measured as plasma Thio Barbituric Acid Reactive substances (TBARS), was found to be elevated significantly (p=0.001) in stomach cancer compared to controls along with a decrease in plasma physiological antioxidant system. The documented results were due to increased lipid peroxidation and involvement of physiological antioxidants in scavenging free radicals but not because of impaired hepatic and renal functions. date: 2010-04-30 date_type: published publication: Online Journal of Health and Allied Sciences volume: 8 number: 4 publisher: Dr. BS Kakkilaya refereed: TRUE referencetext: 1. Ray G, Batra S, Shukla NK, et al. Lipid peroxidation free radical production and antioxidant status in breast cancer. Breast Cancer Res Treat. 2000;59:163-70. 2. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49:33-64. 3. 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FEBS Lett. 1993;331:281–4. 28. Wei M, Schwertner HA, Gibbons LW et al. Low fasting serum bilirubin as a predictor of cancer mortality in men. Hepatology. 2000;32:427A citation: Reddy, EP and Reddy, VS and Chandra Mouli, K and Rao, PVLNS (2010) Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/6979/1/2009-4-9.pdf