?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Glutathione-S-Transferase+and+Thiol+Stress+in+patients+with+acute+renal+failure&rft.creator=Prakash%2C+M&rft.creator=Kedage%2C+V&rft.creator=Muttigi%2C+MS&rft.creator=Nataraj%2C+K&rft.creator=Baig%2C+WW&rft.creator=Attur%2C+RP&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Introduction%3A+Tubular+damage+is+common+finding+in+++acute+renal+failure+(ARF).+Various+etiologies+have+been+put+forth+to+explain+the+tubular+damage+in+ARF%2C+one+important+mechanism+among+them+is+oxidative+damage+to+renal+tubules.+Several+biomolecules+including+low-molecular+weight+peptides+and+enzymes+in+urine+have+been+proposed+as+early+markers+of+renal+failure.+Current+study+has+been+undertaken+to+study+the+thiol+stress+and+glutathione-S-transferase+(GST)+levels+in+ARF+patients.+Method%3A+58+ARF+patients+and+55+healthy+controls+were+selected+based+on+inclusion+and+exclusion+criteria.+Serum+thiols%2C+GST%2C+malanoldehyde+(MDA)+and+urine+thiols+were+determined+by+spectrophotometer+based+methods.+Results%3A+Serum+thiols+and+urine+thiols+were+significantly+decreased+(p%3C0.0001)%2C+and+serum+GST+and+MDA+levels+were+significantly+increased+(p%3C0.0001)+in+ARF+patients+compared+to+healthy+controls.+Serum+GST+and+MDA+correlated+positively+in+ARF+cases+(r2+%3D+0.6938%2C+p%3C0.0001).+Conclusion%3A+There+is+significant+thiol+stress+and+increased+lipid+peroxidation+in+ARF+patients+which+leads+to+tubular+cell+membrane+damage+and+release+of+GST+into+blood+stream+and+into+urine.+This+may+be+possible+mechanism+for+the+increased+presence+of+GST+in+urine+(enzymuria)+found+in+other+studies&rft.publisher=Online+Journal+of+Health+and+Allied+Sciences&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2010-07-30&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7009%2F1%2F2010-2-10.pdf&rft.identifier=++Prakash%2C+M+and+Kedage%2C+V+and+Muttigi%2C+MS+and+Nataraj%2C+K+and+Baig%2C+WW+and+Attur%2C+RP++(2010)+Glutathione-S-Transferase+and+Thiol+Stress+in+patients+with+acute+renal+failure.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7009%2F