--- abstract: " \r\n \r\nEstimates of autism’s incidence increased 5-10 fold in ten years, an increase which cannot be genetic. Though many mutations are associated with autism, no mutation seems directly to cause autism. We need to find the direct cause. Complexity science provides a new paradigm - confirmed in biology by extensive hard data. Both the body and the personality are complex dynamic systems which spontaneously self-organize from simple dynamic systems. Autism may therefore be caused by the failure of a simple dynamic system. \r\n\r\n We know that infants who cannot track their mother’s face often become autistic, that eye-contact initiates intersubjectivity which is blocked in autism, and that the infant-mother pair seems designed to promote eye-contact, as does the eye’s appearance. This author earlier proposed that failure of eye-contact might directly cause autism and that early non-maternal childcare, including television/video, would therefore be statistically linked to autism.\r\n\r\n Waldman et al. (2008; 2006) recently proved that autism is strongly linked to precipitation (indoor activity) and to the introduction of cable. The most plausible explanation? Early exposure to television/video is linked to autism. Furthermore a normal developmental cascade (blocked in autism) has been deciphered: (a) Infant-mother eye-contact triggers increased maternal attention. (b) Early maternal attention permanently increases not only baseline vasopressin but also that oxytocin release which is triggered by subsequent maternal attention. (c) Vasopressin and oxytocin promote face recognition, gazing-at-the-eyes, emotion recognition, and social bonding. \r\n\r\n The eye-contact hypothesis suggests a clinical study addressing prevention: recruit prospective parents who agree to curtail television/video/computer/wi-fi in their families; measure autism’s incidence in their children. \r\n " altloc: - http://www.jungny.com chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - maxmcdowell@jungny.com creators_name: - family: McDowell given: Maxson J. honourific: Dr lineage: '' date: 2010-12-20 date_type: submitted datestamp: 2011-01-11 03:27:22 department: ~ dir: disk0/00/00/71/68 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: - family: Bloom given: Paul honourific: Dr. lineage: '' - family: Finlay given: Barbara honourific: Dr. lineage: '' eprint_status: archive eprintid: 7168 fileinfo: /style/images/fileicons/text_html.png;/7168/1/autism.circulate.1.11.html full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: unpub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: "Autism spectrum disorder;\r\nAsperger's syndrome;\r\nComplexity;\r\nComplex dynamic system;\r\nEye contact;\r\nFace recognition;\r\nInfant-mother dyad;\r\nIntersubjectivity;\r\nOxytocin;\r\nSelf-organized;\r\nEmergent;\r\nEarly television exposure" lastmod: 2011-03-11 08:57:50 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: ~ pagerange: ~ pubdom: TRUE publication: Behavioral and Brain Sciences publisher: Cambridge University Press refereed: FALSE referencetext: " Abrahams, B. S. & Geschwind, D. H. (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics 9, 341-355.\r\n http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756414/\r\n\r\n Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2007). The Molecular Biology of the Cell, Fifth Edition. New York: Garland Science.\r\n\r\nAls, H., Tronic, E. & Brazelton, T. B. (1980). Stages of early behavioral organization: the study of a sighted infant and a blind infant in interaction with their mothers. In: High-Risk Infants and Children, ed. T. M. Field, , 181-204. New York: Academic Press.\r\n\r\nAmerican Academy of Pediatrics Committee on Public Education (2001). Policy Statement: Children, Adolescents, and Television. Pediatrics, 107: 423-6. http://aappolicy.aappublications.org/cgi/content/full/pediatrics;107/2/423\r\n\r\nAndari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting social behavior with oxytocin in high- functioning autism spectrum disorders. Proceedings of the National Academy of Sciences, USA Online, February 16th. \r\n http://www.pnas.org/content/early/2010/02/05/0910249107.full.pdf+html\r\n\r\nAnderson, D. R. & Pempek, (2005). T. A., Television and very young children. American Behavioral Scientist, 48: 505-22. http://abs.sagepub.com/content/48/5/505.abstract\r\n\r\nArthur, W. B. (1999). Complexity and the Economy. Science 2, 284 (5411): 107-9. \r\n http://time.dufe.edu.cn/jingjiwencong/waiwenziliao1/econcomplexweb.pdf\r\n\r\nAsperger H. (1944). Die ‘autischen Psychopathen’ im Kindesalter. Archiv fur Psychiatrie und Nervenkrankheiten, 17: 76-136.\r\n\r\nAuyeung, B., Taylor, K., Hackett, G. & Baron-Cohen, S. (2010). Foetal testosterone and autistic traits in 18 to 24-month-old children. Molecular Autism. 1(11). http://www.molecularautism.com/content/1/1/11\r\n\r\nBaron-Cohen S (1994). How to build a baby that can read minds: cognitive mechanisms in mindreading. Cahiers de Psychologie\r\nCognitive, 13: 513–52.\r\n \r\nBaron-Cohen, S., Wheelwright, S. & Jolliffe, T. (1997). Is there a \"language of the eyes\"? Evidence from normal adults and adults with autism or Asperger syndrome. Visual Cognition, 4(3): 311-31.\r\n\r\nBaron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001): The Autism Spectrum Quotient (AQ): evidence from Asperger syndrome/high functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31:5-17. http://www.autismresearchcentre.com/docs/papers/2001_BCetal_AQ.pdf\r\n\r\nBaron-Cohen, S. (2003). The Essential Difference: Men, Women and the Extreme Male Brain. Penguin, London.[(null)]\r\n\r\nBaron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K. (2005). Sex differences in the brain: implications for explaining autism. Science. Nov 4., 310(5749): 819-23. \r\n http://www.ncbi.nlm.nih.gov/pubmed/16272115\r\n\r\nBeebe, B., Lachman, F. M. & Jaffe, J. (1997). Mother-infant interaction structures and presymbolic self- and object representations. Psychoanalytic Dialogues, 7(2): 133–82.\r\n http://www.pep-web.org/document.php?id=pd.007.0133a\r\n\r\n\r\nBeebe, B. & Lachmann, F. M. (1998). Co-constructing inner and relational processes: Self and mutual regulation in infant research and adult treatment. Psychoanalytic Psychology, 15 (4): 480-516.\r\nhttp://nyspi.org/Communication_Sciences/PDF/Infant%20research%20and%20adult%20treatment/BB-co-constructing%20inner%20and%20relational%203.6.07.pdf\r\n\r\nBeebe, B. (2005). Mother–infant research informs mother–infant treatment. Psychoanalytic Study of the Child, 60: 7-46. (2010). Clinical Social Work Journal, 38: 17-36. \r\n\r\nBergman, A. (1985). From psychological birth to motherhood: the treatment of an autistic child with follow-up into her adult life as a mother. In: Parental influences in health and disease, eds E. J. Anthony and G. H. Pollock, 91-120. Boston: Little, Brown.\r\n\r\nBion, W. R. (1962/1977). Learning from experience . In: Seven Servants. New York: Jason Aronson.\r\n\r\nBroad Institute of MIT and Harvard (2008). Human gene count tumbles again. ScienceDaily. http://www.sciencedaily.com/releases/2008/01/080113161406.htm \r\n\r\nBonabeau, E., Theraulaz, G., Deneubourg, S. A., & Camzine, S. (1997). Self-organization in social insects. Trends in ecology and evolution, 12 (5): 188-93. http://www.biosci.utexas.edu/ib/faculty/mueller/384k/selforganization.PDF\r\n\r\nBower, B. (2009). Joint attention provides clues to autism and cooperation: Different paths to childhood autism. Science News, 176(10): 15. http://www.sciencenews.org/view/generic/id/48055/title/Joint_attention_provides_clues_to_autism_and_cooperation\r\n\r\nBrown, R., Hobson, R. P., Lee, A & Stevenson, J. (1997). Are there \"autistic like\" features in congenitally blind children? Journal of Child Psychology and Psychiatry, 38(6): 693-703. http://www.ncbi.nlm.nih.gov/pubmed/9315979\r\n\r\nByrd, R. (2002). Report to the legislature on the principle findings from \"The epidemiology of autism in California: a comprehensive pilot study.\" http://www.ourstolenfuture.org/NewScience/behavior/2002/2002-10byrd.htm\r\n\r\n\r\nCalifornia Department of Developmental Services (2007). Autism Spectrum Disorders. Changes in the California Caseload An Update: June 1987 – June 2007. \r\n http://www.dds.ca.gov/autism/docs/AutismReport_2007.pdf \r\n\r\nCarver, C. S., & Scheier, M. F. (2000). Perspectives on personality (4th ed.), 5. Boston: Allyn and Bacon. \r\n\r\nChakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill Cawthorne, G., Allison, C., Banerjee-Basu, S., & Baron-Cohen, S. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Research 2(3): 157–77. http://www.ncbi.nlm.nih.gov/pubmed/19598235\r\n\r\nChawarska, K., Volkmar, F., & Klin, A. (2010). Limited attentional bias for faces in toddlers with autism spectrum disorders. Archives of General Psychiatry. 67(2):178-85. http://www.ncbi.nlm.nih.gov/pubmed/20124117\r\n\r\nChimpanzee Sequencing and Analysis Consortium (2005). Initial sequence of the chimpanzee genome and comparison with the human genome. Nature, 437: 69-87. \r\n http://www.nature.com/nature/journal/v437/n7055/full/nature04072.html#a25\r\n\r\nChristakis, D. A., Zimmerman, F. J., DiGiuseppe, D. L. & McCarthy, C. A. (2004). Early Television Exposure and Subsequent Attentional Problems in Children. Pediatrics, 113: 708-13. http://pediatrics.aappublications.org/cgi/content/full/113/4/708\r\n\r\n\r\nChristakis, D. A., Gilkerson, J., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., Gray, S., Yapanel, U. (2009). Audible television and decreased adult words, infant vocalizations, and conversational turns: a population-based study\r\nArchives of Pediatrics & Adolescent Medicine. 2009;163(6):554-558.\r\n http://archpedi.ama-assn.org/cgi/content/abstract/163/6/554 \r\n\r\n Christakis, D. A. (2009). The effects of infant media usage: what do we know and what should we learn? Acta Paediatrica 98(1): 8-16.\r\n\r\n Christakis, D. A. (2010). Internet addiction: a 21st century epidemic?\r\n BioMed Central Medicine. 2010; 8: 61. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972229/?tool=pubmed \r\n\r\nDoheny, K. (2009). Study shows some children may ‘move off’ the autism spectrum. WebMD Health News, May 11th. \r\n http://www.webmd.com/brain/autism/news/20090511/researchers-see-recovery-from-autism\r\n\r\nDunbar, R. I. M. (1992). Neocortex size as a constraint on group size in primates. Journal of Human Evolution, 20: 469-93.\r\nhttp://www.sciencedirect.com/science/article/B6WJS-4F1J80W-G5/2/2f4bddfc940ff3a4b4be2215e17a0c2e \r\n\r\nElman, J. L., Bates, E. A., Johnson, M. H., Karmiloff-Smit, A., Parisi, D. & Plunkett, K. (1998). Rethinking Innateness: A Connectionist Perspective on Development. Cambridge: MIT Press.\r\n\r\nElsabbagh, M., Volein, A., Csibra, G., Holmboe, K., Garwood, H., Tucker, L., Krljes, S., Baron-Cohen, S., Bolton, P., Charman, T., Baird, G., & Johnson, M. H. (2009). Neural Correlates of Eye Gaze Processing in the Infant Broader Autism Phenotype. Biological Psychiatry, 65: 31-8. \r\n http://www.autismresearchcentre.com/docs/papers/2009_Elsabbagh_etal_BiolPsychiatry.pdf\r\n\r\nEmery, N. J. (2000). The eyes have it: the neuroethology, function and evolution of social gaze. Neuroscience and Biobehavioral Reviews, 24: 581-604. http://www.sciencedirect.com/science/article/B6T0J-40XNW1G-1/2/57aa221475c6297b246a8bc1c694230b\r\n\r\nFarroni, T., Csibra, G., Simion, F. & Johnson, M. H. (2002). Eye-contact detection in humans from birth. Proceedings of the National Academy of Sciences USA, 99(14): 9602-5. http://www.pnas.org/content/99/14/9602.long ; \r\nVisual stimuli photographs of direct gaze and averted gaze. http://www.pnas.org/content/99/14/9602/F1.large.jpg\r\n\r\nFarroni, T., Johnson, M. H., Menon, E., Zulian, L., Faraguna, D., & Csibra, G. (2005). Newborns' preference for face-relevant stimuli: Effects of contrast polarity. Proceedings of the National Academy of Sciences USA, 102(47) 17245-50. http://www.pnas.org/content/102/47/17245.full\r\n\r\nFarroni, T., Menon, E., Rigato, S., & Johnson, M. H. (2007). The perception of facial expressions in newborns. European Journal of Developmental Psychology 4(1): 2–13. \r\nhttp://www.informaworld.com/smpp/content~db=all?content=10.1080/17405620601046832\r\n\r\nFriaberg, S. (1977). Insights from the Blind: Comparative Studies of Blind and Sighted Infants. New York: Basic Books.\r\n\r\nFreedman, D. (1964). Smiling in infants and the issue of innate vs. acquired. Journal of Child Psychology and Psychiatry, 5: 171-84.\r\n\r\nFrith U, ed. (1991). Autism and Asperger Syndrome. Cambridge University Press.\r\n\r\nFries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005). Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proceedings of the National Academy of Sciences USA, 102(47): 17237-40. \r\n http://www.pnas.org/content/102/47/17237.full\r\n\r\nGans, C. & Parsons, T. S. (1973). Biology of the Reptiles, 4, Morphology D, 104. London: Academic Press.\r\n\r\nGanz, M. L., (2006). The costs of autism. In: Understanding Autism: From Basic Neuroscience to Treatment, ed. S.O. Moldin and J.L.R. Rubenstein. New York: CRC Press. \r\n\r\n\r\nGanz, M. L., (2007). The lifetime distribution of the incremental societal costs of autism. Archives of Pediatric & Adolescent Medicine. 161(4):343-349.\r\n http://archpedi.ama-assn.org/cgi/content/full/161/4/343#REF-POA60120-1\r\n\r\nGergely, G. (2001). The obscure object of desire: ‘Nearly, but clearly not, like me.’ Contingency preference in normal children versus children with autism. Bulletin of the Menninger Clinic, 65: 411–26. http://web.ceu.hu/phil/gergely/papers/2001_BMC_The_obscure_object_of_desire.pdf \r\n\r\nGergely, G. & Watson, J. S. (1996). The social biofeedback theory of parental affect mirroring. International Journal of Psycho-Analysis, 77: 1181–212. http://web.ceu.hu/phil/gergely/papers/1996_Gergely_Watson_The_social_biofeedback_theory.pdf\r\n\r\nGillberg, C. & Wing, L. (1999). Autism: not an extremely rare disorder. Acta Psychiatrica Scandinavica, 99(6): 399-406. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.1999.tb00984.x/abstract\r\n\r\nGrossmann, T., & Johnson, M. H. (2010). Selective prefrontal cortex responses to joint attention in early infancy. Biology Letters 6(4): 540–543. \r\n http://rsbl.royalsocietypublishing.org/content/6/4/540\r\n\r\nGuastella, A. J., Einfeld, S. L., Gray, K., M., Rinehart, N., J., Tonge, B., J., Lambert, T., J. & Hickie, I., B. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67 (7). \r\nhttp://www.biologicalpsychiatryjournal.com/article/S0006-3223(09)01122-6/abstract\r\n\r\nHaaf, R. A. & Bell, R. Q. (1967). A facial dimension in visual discrimination by human infants. Child Development, 38: 892-9.\r\n\r\nHaith, M. M. (1966). The response of the human newborn to visual movement. Journal of Experimental Child Psychology, 3: 235-43.\r\n\r\nHamermesh, D. S., Frazis, H., & Stewart, J. (2005). Data watch: The American Time Use Survey. Journal of Economic Perspectives, 19: 221-32. \r\n\r\nHobson, R. P., Lee, A. & Brown, R. (1999). Autism and congenital blindness. Journal of Autism and Developmental Disorders, 29(1): 45-56. http://www.ncbi.nlm.nih.gov/pubmed/10097994\r\n\r\nHobson, P. (2002). The Cradle of Thought: Exploring the Origins of Thinking. London: Macmillan.\r\n\r\nHolland, J. (1995) Hidden Order: How Adaptation builds Complexity. Reading, MA: Perseus.\r\n\r\nHolland, J. (1998). Emergence from chaos to order. Reading, MA: Perseus.\r\n\r\nHormatertz-Picciotto, I. & Delwiche, L. (2009), The rise of autism and the role of age in diagnosis. Epidemiology, 20(1): 84-90. http://www.ncbi.nlm.nih.gov/pubmed/19234401\r\n\r\nJaffe, J., Beebe, B., Feldstein, S., Crown, C. L. & Jasnow, M. D. (2001). Rhythms of dialogue in infancy: coordinated timing in development. Monograph of the Society for Research in Child Development, 66(2): i-viii, 1-132. http://www.ncbi.nlm.nih.gov/pubmed/11428150\r\n\r\nJames, I. (2003). Singular scientists. Journal of the Royal Society of Medicine. 96(1): 36–9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539373/\r\n\r\nJanzen, D. H., Hallwachs, W., & Burns, J. M. (2010). A tropical horde of counterfeit predator eyes. Proceedings of the National Academy of Sciences USA, 107(26): 11659-65.\r\nhttp://pubget.com/paper/20547863\r\n \r\nJohnson, M. H. & Morton, J. (1991). Biology and Cognitive Development: The Case of Face Recognition. Oxford: Blackwell.\r\n\r\nKaiser Family Foundation (2003). Zero to six: electronic media in the lives of infants, toddlers, and preschoolers. Kaiser Family Foundation, Menlo Park, CA. http://www.kff.org/entmedia/loader.cfm?url=/commonspot/security/getfile.cfm&PageID=22754\r\n\r\nKaiser Family Foundation (2006) The Media Family: Electronic Media in the Lives of Infants, Toddlers, Preschoolers, and their Parents. Kaiser Family Foundation: Menlo Park, CA. http://www.kff.org/entmedia/upload/7500.pdf\r\n\r\nKaiser, M. D., Hudac, C. M., Shultza, S., Leea, S. M., Cheung, C., Berken, A. M., Deen, B.,Pitskel, N. B., Sugrue, D. R., Voos, A. C., Saulnier, C. A., Ventola, P., Wolf, J. M., Klin, A., Vander Wyk, B. C. & Pelphrey, K. A. (2010). Neural signatures of autism. Proceedings of the National Academy of Sciences, 107(49): 21223-21228. http://www.Pnas.Org/cgi/doi/10.1073/pnas.1010412107\r\n\r\nKarmiloff-Smith, A. (2009). Nativism versus neuroconstructivism: rethinking the study of developmental disorders. Developmental Psychology, 45(1): 56-63.\r\nhttp://www.psyc.bbk.ac.uk/research/DNL/personalpages/aks/Nativism%20vs%20Neuroconstructivism.pdf\r\n\r\n \r\nKlin, A. & Jones, W. (2007). Embodied psychoanalysis? Or, on the confluence of psychodynamic theory and developmental science. In: Developmental Science and Psychoanalysis: integration and innovation, eds L. Mayes, P. Fonagy and M. Target, Karnac, London, 5-38.\r\n\r\nKlin, A. & Jones, W. (2008) Altered face scanning and impaired recognition of biological motion in a 15-month-old infant with autism. Developmental Science 11(1): 40-46. http://www.ingentaconnect.com/content/bpl/desc/2008/00000011/00000001/art00006\r\n\r\nKlin, A., Lin, D. J., Gorrindo, P., Ramsay G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature letters 459, 14 May. \r\n http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758571/\r\n\r\nKlin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002). Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Archives of General Psychiatry, 59(9): 809-16. http://www.ncbi.nlm.nih.gov/pubmed/12215080\r\n\r\nKogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., Singh, G. K., Strickland, B. B., Trevathan, E., & van Dyck, P. C. (2009) National Children's Health Survey Report: Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007. Pediatrics, 124(5): 1395-403.\r\n http://pediatrics.aappublications.org/cgi/content/abstract/peds.2009-1522v1\r\n\r\nLevin, S. A. (1998). Ecosystems and the biosphere as complex adaptive systems. Ecosystems 1: 431-6.\r\n\r\nLoeuille, N. (2009). Evolution of communities an" relation_type: [] relation_uri: [] reportno: ~ rev_number: 162 series: ~ source: ~ status_changed: 2011-01-11 03:27:22 subjects: - behav-neuro-sci - bio-behav - bio-theory - clin-psy - comp-psy - dev-psy - phil-mind - psy-bio succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Eye-contact and complex dynamic systems: an hypothesis on autism’s direct cause and a clinical study addressing prevention.' type: journale userid: 958 volume: ~