creators_name: Nagdeote, AN creators_name: Paunipagar, PV creators_name: Muddeshwar, MG creators_name: Suryawanshi, NP creators_id: abhayanuaru@rediffmail.com editors_name: Kakkilaya, Srinivas editors_id: BS Kakkilaya type: journale datestamp: 2011-05-02 17:17:17 lastmod: 2011-05-02 17:17:17 metadata_visibility: show title: Study of Plasma Ascorbic Acid Levels in Wheezing Children ispublished: pub subjects: OJHAS full_text_status: public keywords: Wheezing; Asthma; Reactive oxygen species; Ascorbic acid abstract: Background: Reactive Oxygen species induced bronchial abnormalities may have important consequences in asthma, the main symptom being wheezing specially in children. Vitamin C is an important antioxidant known to quench the reactive oxygen species. A beneficial effect of fresh fruit consumption on lung function has been observed in several studies. Plasma levels Vitamin C was determined in relation to wheezing symptoms in cross sectional study. Methods: In a cross sectional blood samples of 50 patients attending pediatrics OPD, having wheezing and shortness of breath were analyzed for plasma Ascorbic acid level and compared with healthy controls of same age and sex. Results: The total number of 50 wheezing children were in the age group of 2 to 12 years with similar age matched controls. It was observed that the plasma ascorbic acid concentration in the wheezing children (0.43 – 0.12 mg/dl) was significantly decreased as compared to the normal controls ( 0.75 – 0.18 mg/dl ) P< 0.001. The highly significant low levels of plasma ascorbic acid level in wheezing children was irrespective of sex and severity of symptoms. However the ascorbic acid levels were at the lower side in female and with severe symptoms. Conclusions: Plasma Ascorbic acid levels were significantly, decreased in the process of scavenging the reactive oxygen species. Ascorbic acid directly neutralizes free radical and protects the bronchial tissue from oxidative injury, so it can be concluded that the consumption of fruit rich in vitamin C may reduce wheezing symptoms in children. date: 2011-01-20 date_type: published publication: Online Journal of Health and Allied Sciences volume: 9 number: 4 publisher: BS Kakkilaya refereed: TRUE referencetext: 1. Jarjour MJ, Busse WW, Calnoun WJ. Enhanced production of oxygen radical in nocturnal asthma. Am Rev Resp Dis 1992;146:905. 2. Branes PJ. Reactive oxygen species and airway inflammation. Free radic Biol Med 1990;9:235. 3. Shagun KC, Carcamo JM, Golde DW. Vitamin C entersmitochondria via facilitative glucose transporter 1 (glut 1) and confers mitochondrial protection against oxidative injury. The FASEB Journal 2005;19:1657. 4. Forastiere F, Pistelli R, Sestini P, Fortes C, Renozoni E, Rusconi F et al. Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. Thorax 2000 April;44(4):283. 5. Johnson FC, Sinclair HM. The antioxidant Vitamin C. R C Crit Rev food sci Nutr 1979;11:217. 6. Bui MH, Sauty A, Collet F, Leuenberger P. Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers. J Nutr 1992 Feb;122(2):312. 7. Kyaw A. A Simple colorimetric method for Ascorbic acid determination in blood plasma. Clinical chemica acta 1978;86:153. 8. Barnes PJ. Asthma. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al, editors. Harrison’s principles of internal medicine. 17th ed. New York: McGraw Hill; 2008. p. 1596. 9. Hatch GE. Asthma, Inhaled oxidants, and dietary antioxidants. Am J Clini Nutr 1995;61(suppl):625. 10. Kongerud J, Crissman K, Hatch G, Alexis N. Ascorbic acid is decreased in induced sputum of mild asthmatic children. Inhal Toxicol 2003 Feb;15(2);101. 11. Akinkughe FM, Ette SI. Role of zinc, copper and ascorbicacid in some common clinical pediatric problem. J Trop Peds 1987;33:337. 12. Priest RE. Formation of epithelial basement membrane is restricted by scurvy in vitro and stimulated by vitamin C. Nature 1970;225:74 4. 13. Kalayci O, Besler T, Kiline BE, Saraclar Y. Serum levels of antioxidants vitamins ( alpha tocoferol , beta carotene ,and ascorbic acid) in children with bronchial asthma. Turk J Pediatr 2000;42(1):17. 14. Mohsenin V, Dabois AB, Douglas JS.Effect of ascorbic acid in response to methacholine challenge in asthmatic subjects. Am Rev Resp Dis 1983;127:143. 15. McNally N. Preliminary report on use of vitamin C in asthma. J Irish Med Asso 1953;33:175. citation: Nagdeote, AN and Paunipagar, PV and Muddeshwar, MG and Suryawanshi, NP (2011) Study of Plasma Ascorbic Acid Levels in Wheezing Children. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/7253/1/2010-4-10.pdf