creators_name: Shetty, Prasad K
creators_name: Balaiah, K
creators_name: Nayak, Ganesh
creators_name: Shetty, Prasanna K
editors_name: Kakkilaya, Srinivas
editors_id: BS Kakkilaya
type: journale
datestamp: 2011-05-02 17:16:47
lastmod: 2011-05-02 17:16:47
metadata_visibility: show
title: Thymoma with Myasthenia Gravis in Adolescent
ispublished: pub
subjects: OJHAS
full_text_status: public
keywords: Mediastinal mass; Thymoma; Myasthenia Gravis
abstract: Thymomas are exceedingly rare in the first 20 years of life, Thymic lesions comprise approximately 2–3% of all pediatric mediastinal tumors and include thymic cysts, hyperplasia, carcinoma, and thymomas. Fewer than 30 cases in children have been described in the literature. Thymomas in adults are commonly associated with other diseases, the most frequent being myasthenia gravis. However, this association has been rarely reported in childhood. These tumors are typically  aggressive, with poor outcomes. We report a case of thymoma associated with myasthenia gravis in a 16-year-old girl and review the literature.
date: 2011-01-20
date_type: published
publication: Online Journal of Health and Allied Sciences
volume: 9
number: 4
publisher: BS Kakkilaya
refereed: TRUE
referencetext: 1.	King RM, Telander RL, Smithson WA et al. Primary mediastinal tumors in children. J Pediatr Surg 1982;5:512–20
2.	Cohen AJ, Thompson L, Edwards FH et al. Primary cysts and tumors of the mediastinum. Ann Thorac Surg 1991;51:378–384
3.	Souadjian JV, Enriquez P, Silverstein MN, Pepin JM. The spectrum of diseases associated with thymoma. Arch Intern Med 1974;134:374. 
4.	Simpson JA. Myasthenia Gravis And Myasthenia Syndromes. In: Walton JN, Ed. Disorders of Voluntary Muscle. Edinburgh, London, New York Churchill Livingston, 1974;665-666.
5.	Bertelse S, Malmstrom J, Heerfordt J et al. Tumors of the thymic region—symptomatology, diagnosis, treatment and prognosis. Thorax 1975;30:19–25
6.	Masaoka A, Monden Y, Nakahara K et al. Following study of thymoma with special reference to their clinical stages. Cancer 1981;48:2485–2492
7.	Haniuda M, Miyazawa M, Yoshida et al. Is postoperative radiotherapy for thymoma effective? Ann Surg 1996;224:219–224
8.	Fornasiero A, Daniele O, Ghiotto C et al. Chemotherapy for invasive thymoma. A 13-year experience. Cancer 1991;68:30–33
9.	Legg MA, Brady WJ. Pathology and clinical behavior of thymomas: A survey of 5 1 cases. Cancer 1968;18(9):1131-1144.
10.	Namba T. Brunner NG, Grob D. Myasthenia gravis in patients with thymoma with particular reference to onset after thymectomy. Medicine 1978;57:4.
11.	Rodriguez M, Gomez MR, Howard FM, Taylor WF. Myasthenia gravis in children: Long-term follow-up. Ann Neurol 1983;13:504-510.
12.	Cavanagh NPC. The role of thymectomy in childhood myasthenia. Develop Med Child Neurol 1980;22:668-674.
citation:   Shetty, Prasad K and Balaiah, K and Nayak, Ganesh and Shetty, Prasanna K  (2011) Thymoma with Myasthenia Gravis in Adolescent.  [Journal (On-line/Unpaginated)]     
document_url: http://cogprints.org/7259/1/2010-4-16.pdf