creators_name: B, Praveen Kumar creators_name: S, Sudhakar creators_name: MPV, Prabhat creators_id: dr_praveenrao@yahoo.co.in editors_name: Kakkilaya, Srinivas editors_id: BS Kakkilaya type: journale datestamp: 2011-05-02 17:14:59 lastmod: 2011-05-02 17:14:59 metadata_visibility: show title: Congenital Insensitivity to Pain ispublished: pub subjects: OJHAS full_text_status: public keywords: Congenital; Pain; Insensitivity; Nerve; HSAN abstract: Congenital Insensitivity to Pain belongs to the family of Hereditary Sensory and Autonomic Neuropathies (HSAN). It is a rare disorder of unknown etiology associated with loss of pain sensation. Cognition and sensation is otherwise normal and there is no detectable physical abnormality. We report a case of Congenital Insensitivity to Pain in a 3 year old female child. date: 2011-01-20 date_type: published publication: Online Journal of Health and Allied Sciences volume: 9 number: 4 publisher: BS Kakkilaya refereed: TRUE referencetext: 1. Merskey H, Bogduk N, editors. Classification of chronic pain, Task Force on Taxonomy, International Association for the Study of Pain. 2nd ed. Seattle: IASP Press: 1994. p. 210-213. 2. Cox JJ et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006;444:894-898. 3. Unknown author. Insensitivity to pain. BMJ 1973;27:187-188. 4. Nishida G. Congenital Anhidrosis. Saishin Igaku (Japan) 1951;6:1100-1104. 5. Drenth JPH, Waxman SG. Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J. Clin. Invest 2007;117(12):3603-3609. 6. Protheroe SM. Congenital insensitivity to pain. Journal of the Royal Society of Medicine 1991;84:558-559. 7. Felicia B, Max J. Inherited Autonomic Neuropathies. Seminars in Neurology 2003;23(4). 8. Pinsky L, DiGeorge AM. Congenital familial sensory neuropathy with anhidrosis. J Pediatr 1966;68:1-13. 9. National Institute of Neurological Disorders and Stroke: NINDS Lesch-Nyhan Syndrome Information Page. Available at: http://www.ninds.nih.gov/disorders/lesch_nyhan/lesch_nyhan.htm. Accessed February 13, 2007 10. Medscape’s Continually Updated Clinical Reference: Lesch-Nyhan Syndrome. Available at: http://emedicine.medscape.com/article/1181356-overview. Accessed Jun 29th, 2010. 11. Edwards-Lee TA. Cornford ME, Yu K-T T. Congenital insensitivity to pain and anhidrosis with mitochondrial and axonal abnormalities. Pediatr Neurol 1997;17:356-361. 12. Serendip Update's blog: Congenital Insensitivity to Pain with Anhidrosis. Available at: http://serendip.brynmawr.edu/exchange/node/1736. Accessed April 1st, 2008. citation: B, Praveen Kumar and S, Sudhakar and MPV, Prabhat (2011) Congenital Insensitivity to Pain. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/7276/1/2010-4-29.pdf