?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Evolving+clinical+profile+of+HLA-DRB1%2C+MMP1+and+NF-%CE%9Ab+gene+in+rheumatoid+factor+positive+Caucasian+population+&rft.creator=Anupama+Sharma%2C+Ajay+kumar+Singh%2C+Sanjeev+kumar+Singh%2C+Neelima+Singh%2C+Varsha+Gupta+Int+J+Cur+Sci+Res.+&rft.subject=JOURNALS&rft.description=Rheumatoid+arthritis+(RA)%2C+a+systemic+autoimmune+condition%2C+causes+joint+damage+and+sometimes+extra-articular+lesions+(cutaneous+vasculitis%2C+neuropathy%2C+Felty%E2%80%99s+syndrome%2C+pericarditis%2C+intersticial+lung+disease)+that+may+be+life+threatening.+The+reason+why+extra-articular+features+will+develop+in+rare+RA+patients+is+unknown.+Our+study+was+aimed+to+find+any+disease+correlation+with+respect+to+a+few+genetic+loci+implicated+in+rheumatoid+arthritis.+In+our+study+no+significant+association+was+observed+for+NFkB1+and+MMP-1.+However+HLA-DRB1+showed+polymorphism+in+RA+and+controls.+The+study+was+conducted+on+60+patients%2C+where+30+were+control+and+30+were+diseased.+All+the+patients+selected+for+the+study+were+RF+(rheumatoid+factor)+positive.+Therefore+the+studies+need+to+be+conducted+on+larger+group+of+patients%2C+so+that+the+association+can+be+verified+in+Caucasian+population+(Indian+scenario).&rft.publisher=CurrentSciDirect+Publications&rft.date=2011-04-30&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7305%2F1%2FEvolving_clinical_profile_of_HLA-DRB1%252C_MMP1_and_NF-%25CE%259Ab_gene_in_rheumatoid_factor_positive_Caucasian_pop.pdf&rft.identifier=++Anupama+Sharma%2C+Ajay+kumar+Singh%2C+Sanjeev+kumar+Singh%2C+Neelima+Singh%2C+Varsha+Gupta+Int+J+Cur+Sci+Res.+++(2011)+Evolving+clinical+profile+of+HLA-DRB1%2C+MMP1+and+NF-%CE%9Ab+gene+in+rheumatoid+factor+positive+Caucasian+population.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7305%2F