---
abstract: 'Introduction: Primary hyperparathyroïdism is observed in 35 to 44 subjects/ 100000 persons. The increased production of parathyroid hormones is secondary to primary glandular modifications consisting mainly in adenomas. The authors report a clear-cell hyperplasia causing primary hyperparathyroidism. Observation: We report the case of a 25-year-old man who was admitted to explore pathologic fractures of the left arm and a malignant hypercalcaemia. Complementary laboratory tests revealed primary hyperparathyroidism. A multiple endocrine neoplasia was excluded by radiologic examinations. Cervical ultra-sound examination revealed 2 parathyroid adenomas and per-operative exploration showed 3 « adenomas ». Microscopic examination of the 4 parathyroid glands specimen concluded to a clear cell hyperplasia.  Conclusion: Clear cell hyperplasia is a benign cause of primary hyperparathyroidism. The diagnosis is based upon histologic findings and examination of the 4 glands. '
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  - mlika.zorgati.mona@hotmail.com
creators_name:
  - family: 'Mona Mlika, Zidi-Moaffak Y  , Lakhoua  Y, Farah  F, Kourda  N, Ben Abdallah  N, Zermani  R,  Baltagi-Ben Jilani  S '
    given: 'Int J Cur Bio Med Sci. '
    honourific: ''
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date: 2011-04-30
date_type: published
datestamp: 2011-05-02 15:52:21
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keywords: 'Clear cell hyperplasia, hyperparathyroidism, management'
lastmod: 2011-05-02 15:52:21
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number: 2
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publication: 'Int J Cur Bio Med Sci. '
publisher: CurrentSciDirect Publications
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referencetext: "[1]\tDelellis A. Atlas of tumor pathology. Tumors of parathyroid gland. Washington DC: Armed Forces Institute of Pathology, 1993.\r\n[2]\tBégueret H, Belleannée G, Dubrez J, Trouette H, Parrens M, Velly JF et al. Clear cell parathyroid adenoma : A rare and challenging lesion. Ann Pathol. 1999 ;19(4) :316-319.\r\n[3]\tMiddleton LP, Merino MJ. The parathyroid glands. In: X. Head and Neck Surgical Pathology. Philadelphia: Lippincott Williams and Wilkins, 2001.\r\n[4]\tLawrence DA. A histological comparison of adenomatous and hyperplastic parathyroid glands. J Clin Pathol.. 1978; 31:626-632.\r\n[5]\tPersson S, Hansson G, Hedman I, Tisell LE, Widéehn S. Primary parathyroid hyperplasia of water-clear cell type. Transformation of water-clear cells into chief cells. Acta Pathol Microbiol Immunol Scand. 1986; 94(6):391-395.\r\n\r\n\r\n\r\n"
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status_changed: 2011-05-02 15:52:21
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title: About A Rare Cause Of Primary Hyperparathyroidism
type: journalp
userid: 13352
volume: 1
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