--- abstract: "Cholecystitis is inflammation of the gallbladder that develops in short time usually when gallstone obstructs the cystic duct. Patients over the passage of time land to chronic cholecystitis. They have an abnormal liver function test with clinical features suggestive of gall bladder disease. Therefore, systematic step by step reviews of various investigations are important in diagnosis of gall bladder disease. The first step includes clinical evaluation of the patient followed by estimation of enzyme markers.. The seriousness of disease can be estimated from combined information of clinical examination & specialized biochemical tests. Specialized enzymatic markers are helpful for proper follow-up as delay can be devastating. It can form a platform for malignant & cirrhotic changes of liver: Present study has been undertaken to avoid dreads by simple clinical enzyme study. Serum levels of 5’NT/ALP/AST/ALT/Bilirubin were estimated in sixty cases of clinically diagnosed cholecystitis against forty normal individuals. Purpose was to single out a parameter which is most significant & may help as an endoscope to \r\nSurgeon for timely intervention. The study delineates5’NT to be superior to ALP due to its specificity &. Sensitivity. While elevated AST & ALT levels signify extent of hepatic cell damage, 5”NT specifically signifies the bile duct obstruction or cholestasis as well as hepatic cell damage. \r\n" altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Anil Batta given: 'Int J Cur Biomed Phar Res. ' honourific: '' lineage: '' date: 2011-04-30 date_type: published datestamp: 2011-05-02 15:51:52 department: ~ dir: disk0/00/00/73/25 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 7325 fileinfo: /style/images/fileicons/application_pdf.png;/7325/1/Cholecystitis_%26_An_Enzyme_Study.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Liver function, enzyme markers, clinical evaluation, gall bladder. ' lastmod: 2011-05-02 15:51:52 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 2 pagerange: 11-14 pubdom: TRUE publication: 'Int J Cur Biomed Phar Res. ' publisher: CurrentSciDirect Publications refereed: TRUE referencetext: "[1]\tMohan H, Textbook of pathology, 4th ed, Jaypee Publisher, Delhi. 2000; 569-571.\r\n[2]\tHenry JB, Clinical diagnosis and management by laboratory methods, 17th ed, WB Saunders\r\n[3]\tCompany, Philadelphia. 2001; 217-250.\r\n[4]\tGitnick G, Disease of the liver and biliary tract, Mosby Year Book Inc, St. Louis. 1992; 137-182.\r\n[5]\tO’Grady JG, Lake JR, Howdle PD, Comprehensive Clinical Hepatology, Mosby, London. 2000; 4:1-5.\r\n[6]\t5. Zakin D, Boyer TD, Hepatology: a textbook of liver disease, 3rd ed, WB Saunders, Philadelphia. 1996; 791–833.\r\n[7]\tSchiff L, Schiff ER, Diseases of the liver, 7th ed, JB Lippincott, Philadelphia, 1993; 108–144.\r\n[8]\tTygstrup N, Assessment of liver function: principles and practice, J Gastroenterol Hepatol. 1990; 5: 468–482.\r\n[9]\tLum G, Gambino SR, Serum gamma-glutamyl transpeptidase activity as an indicator of disease of liver, pancreas, or bone, Clin Chem. 1972; 18: 358–362.\r\n[10]\tGodkar PB, Godkar DP, Text book of Medical Laboratory Technology, 2nd ed, Bhalani Publishing House, Mumbai. 2003; 331-351.\r\n[11]\tDickson ER, Grambsch PM, Fleming TR, Fisher LD, Langworthy A, Prognosis in primary biliary cirrhosis: model for decision making, Hepatology. 1989;10: 1–7.\r\n[12]\tGordon T, Factors associated with serum alkaline phosphatase level. Arch Pathol Lab Med. 1993;117: 187–190.\r\n[13]\tBelfield A, Goldberg DM, Normal ranges and diagnostic value of serum 5’-nucleotidase and alkaline phosphatase activities in infancy. Arch Dis Child. 1971;46: 842–846.\r\n[14]\tSeitanidis B, Moss DW, Serum alkaline phosphatase and 5’- nucleotidase levels during normal pregnancy. Clin Chim Acta. 1969;25: 183–184.\r\n[15]\tKirsch R, Frith L, Black E, Hoffenberg R, Regulation of albumin synthesis and catabolism by alteration of dietary protein. Nature. 1968;217: 578–579.\r\n[16]\tKeshgegian AA, Hypoalbuminemia associated with diffuse hypergamma-globulinemia in chronic diseases: lack of diagnostic specificity. Am J Clin Pathol. 1984;81:477–481.\r\n[17]\tSuttie JW, Jackson CM, Prothrombin structure, activation and biosynthesis, Physiol Rev. 1977;57:47-46. \r\n[18]\tLinnet K, Kelbaek H, The patterns of glycine and taurine conjugates of bile acids in serum in hepatobiliary disease. Scand J Gastroenterol. 1982;17: 919–924. \r\n \r\n\r\n\r\n" relation_type: [] relation_uri: [] reportno: ~ rev_number: 18 series: ~ source: ~ status_changed: 2011-05-02 15:51:52 subjects: - JOURNALS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Cholecystitis & An Enzyme Study type: journalp userid: 13362 volume: 1