?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Prevention+of+endotoxin-induced+uveitis+in+rabbits+by+Triphala%2C+an+Ayurvedic+formulation&rft.creator=Suresh+Kumar+Gupta%2C+V.+Kalaiselvan%2C+Shyam+Sunder+Agrawal%2C+Sushma+Srivastava%2C+Rohit+Saxena%2C+Int+J+Cur+Biomed+Phar+Res.+&rft.subject=JOURNALS&rft.description=Purpose%3A+Triphala+(TA)+is+an+Ayurvedic+formulation+used+to+treat+various+disorders.+The+present+study+was+designed+to+investigate+the+anti-inflammatory+effect+of+TA+aqueous+extract+on+experimental+uveitis+in+the+rabbit.+++Methods%3A+Anterior+uveitis+was+induced+in+rabbits+by+intravitreal+injection+of+lipopolysaccharide+from+Eschericha+coli+after+pretreatment+with+TA+aqueous+extract.++Subsequently+the+anti-inflammatory+activity+of+TA+was+evaluated+by+grading+the+clinical+signs+and+estimating+the+inflammatory+cell+count%2C+protein%2C+and+TNF-%CE%B1+level+in+the+aqueous+humour.+Results%3A+The+anterior+segment+inflammation+in+the+control+group+was+significantly+higher+than+in+TA+and+prednisolone+treated+groups%2C+as+observed+by+clinical+grading.++The+inflammatory+cell+count+in+the+control+group+was+31.23+%C2%B1+0.80+%C3%97+105cells%2Fml%2C+whereas+it+was+3.29+%C2%B1+0.47+%C3%97+105cells%2Fml+(P+%3C+0.0001+vs.+control)+and+1.31+%C2%B1+0.31+%C3%97+105+(P+%3C++0.0001+vs.+control)+cells%2Fml+in+the+TA+and+prednisolone+treated+groups%2C+respectively.++The+protein+content+of+the+aqueous+humour+was+15.43+%C2%B1+0.54%2C+3.13+%C2%B1+0.35+(P+%3C+0.0001+vs.+control)%2C+and+1.96+%C2%B1+0.39+(P+%3C+0.0001+vs.+control)+mg%2Fml+in+the+control%2C+TA+and+prednisolone+treated+groups+respectively.++The+aqueous+TNF-+%CE%B1+level+in+the+control+group+was+942.20+%C2%B1+6.46+pg%2Fml+and+was+261.30+%C2%B1+13.60+(P+%3C+0.001+vs.+control)+and+104.00+%C2%B1+4.50+(P+%3C+0.0001+vs.+control)+pg%2Fml+in+the+TA+and+prednisolone+treated+groups%2C+respectively.++%0D%0AConclusions%3A+Topical+administration+of+aqueous+extract+of+TA+prevented+uveitis+in+endotoxin-induced+experimental+rabbits.%0D%0A&rft.publisher=CurrentSciDirect+Publications&rft.date=2011-04-30&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7327%2F1%2FPrevention_of_endotoxin-induced_uveitis_in_rabbits_by_Triphala%252C_an_Ayurvedic_formulation.pdf&rft.identifier=++Suresh+Kumar+Gupta%2C+V.+Kalaiselvan%2C+Shyam+Sunder+Agrawal%2C+Sushma+Srivastava%2C+Rohit+Saxena%2C+Int+J+Cur+Biomed+Phar+Res.+++(2011)+Prevention+of+endotoxin-induced+uveitis+in+rabbits+by+Triphala%2C+an+Ayurvedic+formulation.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7327%2F