?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Antipyretic+activity+of+azima+tetracantha+++in+experimental+animals+&rft.creator=Tajuddin+Nargis+Begum%2C+++Mohamed+Hussain+Muhammad+Ilyas%2C++Arumugam+Vijaya+Anand+%2C+Int+J+Cur+Biomed+Phar+Res.+&rft.subject=JOURNALS&rft.description=In+the+present+study%2C+the+ethanolic+leaf+extract+of+Azima+tetracantha+Lam+(A.+tetracantha)+was+investigated+for+antipyretic+activity+in+rats+using+Brewer%E2%80%99s+yeast+induced+Pyrexia.++The+leaves+of+A.+tetracantha+were+collected+from+Ponnamaravathi+and+cut+into+small+pieces+and+shade+dried.+The+dried+powdered+leaves+(100+gm)+were+extracted+in+a+Soxhlet+apparatus+by+using+95%25+ethanol.++Albino+rats+weighing+(200-250g)+were+taken+for+the+experiment+divided+into+four+groups+of+six+animals+each.+Group+1+received+3%25+aqueous+suspension+of+gum+Acacia+(1+ml%2F200g)+as+vehicle+orally%2C+group+2+and+group+3+received+ethanolic+leaf+extract+of+A.+tetracantha+100+and+200+mg%2Fkg+with+3%25+aqueous+suspension+of+gum+Acacia+orally+and+the+group+4+served+as+standard+received+paracetamol+25+mg%2Fkg+with+3%25+aqueous+suspension+of+gum+Acacia+orally.+The+subcutaneous+injection+of+yeast+suspension+markedly+elevated+the+rectal+temperature+after+18h+of+administration.++Treatment+with+A.+tetracantha+extract+at+a+dose+of+100%2C+200+mg%2Fkg+decreased+the+rectal+temperature+of+the+rats+in+dose+dependent+manner.++This+effect+was+maximal+at+dose+of+200+mg%2Fkg+and+it+caused+significant+lowering+of+body+temperature+(P%3C+0.01)+up+to+4+hour+after+its+administration.++The+antipyretic+effect+started+as+early+as+1h+and+the+effect+was+maintained+for+4h%2C+after+its+administration.+++Both+the+standard+drug+paracetamol+25+mg%2Fkg+and+tested+drug+A.+tetracantha+extract+were+significantly+reduced+the+yeast+elevated+rectal+temperature%2C+at+2nd%2C+3rd+and+4th+hour+compared+to+control+group.&rft.publisher=CurrentSciDirect+Publications&rft.date=2011-04-30&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7331%2F1%2FAntipyretic_activity_of_azima_tetracantha___in_experimental_animals_.pdf&rft.identifier=++Tajuddin+Nargis+Begum%2C+Mohamed+Hussain+Muhammad+Ilyas%2C+Arumugam+Vijaya+Anand+%2C+Int+J+Cur+Biomed+Phar+Res.+++(2011)+Antipyretic+activity+of+azima+tetracantha+in+experimental+animals.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7331%2F