---
abstract: "The brain's sensitivity to unexpected outcomes plays a fundamental role in an\r\norganism's ability to adapt and learn new behaviors. Emerging research suggests that\r\nmidbrain dopaminergic neurons encode these unexpected outcomes. We used\r\nmicroelectrode recordings during deep brain stimulation surgery to study neuronal activity in\r\nthe human substantia nigra (SN) while patients with Parkinson's disease engaged in a\r\nprobabilistic learning task motivated by virtual financial rewards. Based on a model of the ..."
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creators_name:
  - family: Zaghloul
    given: K.A.
    honourific: ''
    lineage: ''
  - family: Blanco
    given: J.A.
    honourific: ''
    lineage: ''
  - family: Weidemann
    given: C.T.
    honourific: ''
    lineage: ''
  - family: McGill
    given: K.
    honourific: ''
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  - family: Jaggi
    given: J.L.
    honourific: ''
    lineage: ''
  - family: Baltuch
    given: G.H.
    honourific: ''
    lineage: ''
  - family: Kahana
    given: M.J.
    honourific: ''
    lineage: ''
date: 2009
date_type: published
datestamp: 2011-12-16 00:10:00
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dir: disk0/00/00/77/13
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eprintid: 7713
fileinfo: application/pdf;http://cogprints.org/7713/1/ZaghloulEtAl2009.pdf|application/pdf;http://cogprints.org/7713/6/ZaghloulEtAl2009_sup.pdf
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lastmod: 2011-12-16 00:10:00
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number: 5920
pagerange: 1496-1499
pubdom: TRUE
publication: Science
publisher: American Association for the Advancement of
refereed: TRUE
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rev_number: 10
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status_changed: 2011-12-16 00:10:00
subjects:
  - cog-psy
  - psycphs
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title: Human substantia nigra neurons encode unexpected financial rewards
type: journalp
userid: 6246
volume: 323
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