---
abstract: 'Aperiodic entrainment to rhythmic sensory input was obtained with either a single neuron or an excitatory network model, without addition of a stochastic or "noisy" element. The entrainment properties of primary sensory neurons were well captured by the dynamics of the Hodgkin-Huxley ordinary differential equations with a quiescent resting state or threshold for spike output. The frequency-amplitude parameter space was compressed and aperiodic regimes were small in comparison to those of periodically activated pacemaker like neurons. Transitions between phase-locked and aperiodic entrainment patterns were predictable and determined by the equation dynamics; supporting the contention that some aperiodicities observed ${in}$ ${situ}$ arise from the inherent membrane properties of neurons. When the rhythmically activated neuron was embedded in an excitatory network of Hodgkin-Huxley neurons with heterogeneous synaptic delays, aperiodic entrainment patterns were more frequently encountered and these were associated with asynchronous output from the network. Embedding the rhythmically activated neuron in a network with synaptic delays, greatly reduced the range of entrained spike frequencies. Other biological mechanisms of modifying the entrainment properties and promoting aperiodic entrainment are discussed.'
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creators_name:
  - family: Read
    given: Heather L
    honourific: ''
    lineage: ''
  - family: Siegel
    given: Ralph M
    honourific: ''
    lineage: ''
date: 1996
date_type: published
datestamp: 1998-03-16
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dir: disk0/00/00/00/08
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eprintid: 8
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keywords: 'sensory, neuron, irregular, synchronous, asynchronous, dynamic, entrainment'
lastmod: 2011-03-11 08:53:36
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number: 1
pagerange: 301-314
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publication: Neuroscience
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rev_number: 8
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status_changed: 2007-09-12 16:21:36
subjects:
  - neuro-neu
  - neuro-physio
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title: On the origins of aperiodicities in sensory neuron entrainment
type: journalp
userid: 140
volume: 75
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