creators_name: Amita, K creators_name: Vijay Shankar, S creators_name: Abhishekh, MG creators_name: Geethalakshmi, U creators_id: dramitay@rediffmail.com creators_id: vijayshankarpatho@gmail.com editors_name: Kakkilaya, Srinivas editors_id: BS Kakkilaya type: journale datestamp: 2012-11-09 17:37:18 lastmod: 2012-11-09 17:37:18 metadata_visibility: show title: Emperipolesis in a Case of Adult T Cell Lymphoblastic Lymphoma (Mediastinal type)-Detected at FNAC and Imprint Cytology ispublished: pub subjects: OJHAS full_text_status: public keywords: Emperipolesis; Lymphoblastic lymphoma; Imprint cytology; Rosai Dorfman disease; Fine needle aspiration cytologyy abstract: Emperipolesis is a condition in which viable hematopoetic cells are seen intact in the cytoplasm of host cell without damage. This phenomenon is seen in many physiologic and pathologic conditions, its presence in Rosai Dorfman disease (RDD) is characteristic of the disease. However emperipolesis is an uncommon finding in malignant lymphoma both Hodgkins and non-Hodgkin’s lymphoma, wherein it has been described in bone marrow aspirate and tissue culture. In contrast there are only two case reports of emperipolesis phenomenon described in non-Hodgkin’s lymphoma in tissue sections. We report a case of an adult T cell lymphoblastic lymphoma (mediastinal type) with features of emperipolesis demonstrated at fine needle aspiration cytology (FNAC) and imprint cytology of cervical lymph nodes. To our knowledge, this is the first case report of emperipolesis in a case of adult T cell lymphoblastic lymphoma (mediastinal type)-detected at FNAC and imprint cytology. date: 2011-11-15 date_type: published publication: Online Journal of Health and Allied Sciences volume: 10 number: 3 publisher: BS Kakkilaya refereed: TRUE referencetext: 1. Lopes LF, Bacchi MM, Coelho KI, Filho AA, Bacchi CE. Emperipolesis in a case of B-cell lymphoma: a rare phenomenon outside of Rosai-Dorfman disease. Ann Diagn Pathol 2003;7(5):310-313. 2. Djaldetti M, Strauss Z. Emperipolesis by megakaryocytes in patients with non-Hodgkin's lymphoma and megaloblastic anemia. J Submicrosc Cytol1982;14(2):407-413. 3. Takeya M, Takahashi K. Emperipolesis in a case of malignant lymphoma: electron microscopic and immunohistochemical investigation. Ultrastruct Pathol 1988;12(6):651-658. 4. Humble JG, Jayne WHW, Pulvertaft RJV. Biological interaction between lymphocytes and other cells. Brit J Haematol 1956;2:283–294 5. Poppema S. Sternberg-Reed cells with intracytoplasmic lymphocytes. Phagocytosis or emperipolesis? Virchows Arch A Pathol Anat Histol 1978;380(4):355-359. 6. Schumacher HR, Szekely IE, Fisher DR. Research, serendipity, and emperipolesis. The Lancet 1974;303(7861):812-827 7. Lee WB, Erm SK, Kim KY, Becker RP. Emperipolesis of erythroblasts within Kupffer cells during hepatic hemopoiesis in human fetus. Anat Rec 1999;256(2):158-164. 8. Sherwin RP, Margolick JB. Emperipolesis or phagocytosis by Reed-Sternberg cells? The New England Journal of medicine 1979;301(24):1348-1349. 9. Samii K, Pasteur E. Images in hematology. Emperipolesis. Am J Hematol 1998;59(1):64. 10. Dziecioł J, Lemancewicz D, Kłoczko J, Bogusłowicz W, Lebelt A. Megakaryocytes emperipolesis in bone marrow of the patients with non-Hodgkin's lymphoma. Folia Histochem Cytobiol 2001;39 suppl 2:142-143. 11. Nerurkar AY, Krishnamurthy S. Emperipolesis as a key feature in imprint cytology of the thymus. A report of two cases. Acta Cytol 2000;44(6):1059-1061. citation: Amita, K and Vijay Shankar, S and Abhishekh, MG and Geethalakshmi, U (2011) Emperipolesis in a Case of Adult T Cell Lymphoblastic Lymphoma (Mediastinal type)-Detected at FNAC and Imprint Cytology. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/8008/7/2011-3-11.pdf