?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Dopaminergic+Regulation+of+Neuronal+Circuits+in+Prefrontal+Cortex&rft.creator=Scheler%2C+Gabriele&rft.subject=Cognitive+Psychology&rft.subject=Computational+Neuroscience&rft.subject=Neural+Nets&rft.subject=Neural+Modelling&rft.subject=Neuropsychology&rft.subject=Neuropsychiatry&rft.description=Neuromodulators%2C+like+dopamine%2C+have+considerable+influence+on+the%0D%0Aprocessing+capabilities+of+neural+networks.+%0D%0AThis+has+for+instance+been+shown+in+the+working+memory+functions%0D%0Aof+prefrontal+cortex%2C+which+may+be+regulated+by+altering+the%0D%0Adopamine+level.+Experimental+work+provides+evidence+on+the+biochemical%0D%0Aand+electrophysiological+actions+of+dopamine+receptors%2C+but+there+are+few+%0D%0Atheories+concerning+their+significance+for+computational+properties+%0D%0A(ServanPrintzCohen90%2CHasselmo94).%0D%0AWe+point+to+experimental+data+on+neuromodulatory+regulation+of+%0D%0Atemporal+properties+of+excitatory+neurons+and+depolarization+of+inhibitory+%0D%0Aneurons%2C+and+suggest+computational+models+employing+these+effects.%0D%0AChanges+in+membrane+potential+may+be+modelled+by+the+firing+threshold%2C%0D%0Aand+temporal+properties+by+a+parameterization+of+neuronal+responsiveness+%0D%0Aaccording+to+the+preceding+spike+interval.%0D%0AWe+apply+these+concepts+to+two+examples+using+spiking+neural+networks.%0D%0AIn+the+first+case%2C+there+is+a+change+in+the+input+synchronization+of%0D%0Aneuronal+groups%2C+which+leads+to%0D%0Achanges+in+the+formation+of+synchronized+neuronal+ensembles.%0D%0AIn+the+second+case%2C+the+threshold%0D%0Aof+interneurons+influences+lateral+inhibition%2C+and+the+switch+from+a+%0D%0Awinner-take-all+network+to+a+parallel+feedforward+mode+of+processing.%0D%0ABoth+concepts+are+interesting+for+the+modeling+of+cognitive+functions+and+may%0D%0Ahave+explanatory+power+for+behavioral+changes+associated+with+dopamine+%0D%0Aregulation.&rft.date=2001-08-10&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F8082%2F1%2Fneural-networks-2012.pdf&rft.identifier=++Scheler%2C+Gabriele++(2001)+Dopaminergic+Regulation+of+Neuronal+Circuits+in+Prefrontal+Cortex.++%5BJournal+(On-line%2FUnpaginated)%5D++++(In+Press)++&rft.relation=http%3A%2F%2Fcogprints.org%2F8082%2F