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abstract: Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the same mice. For collaborators interested in premade catheters for research please make a request at www.neuro-cloud.net/nature-precedings/pomerenze.
altloc:
- http://www.neuro-cloud.net
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id: []
creators_name:
- family: Pomrenze
given: M
honourific: ''
lineage: ''
- family: Baratta
given: M
honourific: ''
lineage: ''
- family: Cadle
given: B
honourific: ''
lineage: ''
- family: Cooper
given: D.C.
honourific: ''
lineage: ''
date: 2012-03-29
date_type: published
datestamp: 2012-11-09 19:37:13
department: ~
dir: disk0/00/00/81/43
edit_lock_since: ~
edit_lock_until: 0
edit_lock_user: ~
editors_id: []
editors_name: []
eprint_status: archive
eprintid: 8143
fileinfo: application/pdf;http://cogprints.org/8143/1/pom%2D13.pdf|text/plain;http://cogprints.org/8143/7/bibliography.txt
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: unpub
issn: ~
item_issues_comment: []
item_issues_count: ~
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'mouse self-administration, intravenous catheter, addiction'
lastmod: 2012-11-09 19:37:13
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: ~
pubdom: TRUE
publication: Nature Precedings
publisher: Nature Publishing Group
refereed: FALSE
referencetext: "1. Kelley, B.M. et al. (1997). Phys and Behv, 62(1): 163 167. \r\n2. Thomsen, M. et al. (2006). Psychopharm, 184: 145 154. \r\n3. Chen, B.T et al. (2008). Neuron, 59: 288-297 . \r\n4. Caine, S.B. et al. (1999). Psychopharm, 147: 22-24. Page 2 of 2"
relation_type: []
relation_uri: []
reportno: ~
rev_number: 8
series: ~
source: ~
status_changed: 2012-11-09 19:37:13
subjects:
- behav-neuro-sci
- neuro-pharm
succeeds: 8141
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation'
type: journalp
userid: 16482
volume: March