?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+effect+of+pretreatment+with+plant+extract%2C+nicotine+and+caffeine+on+sleeping+time+induced+by+pentobarbitone+in+mice&rft.creator=Robson%2C+Noorzurani&rft.creator=Mustafa%2C+A.+M.&rft.subject=Social+Psychology&rft.description=Objective%3A+To+determine+the+effects+of+plant+extract%2C+nicotine+and+caffeine+on+the+activities+of+the+liver+metabolizing-enzyme+induced+by+pentobarbitone.+Materials+and+Method%3A+Seven+groups+of+mice+were+pretreated+with+high+doses+of+sample+extracts+(0.4+mg%2Fg+body+weight+sample+extract%2C+but+nicotine+at+0.1+mg%2Fg+body+weight)+and+one+control+group+was+pretreated+with+saline.+On+day+5%2C+pentobarbitone+(0.005+ml+of+8+mg%2Fml)+was+administered+and+the+sleeping+time+was+determined.+The+test+was+repeated+but+at+low+doses+(0.1+mg%2Fg+body+weight+sample+extract%2C+but+nicotine+at+0.05mg%2Fg+body+weight).+Results%3A+At+high+doses%2C+bitter+gourd%2C+'tempeh'%2C+nicotine%2C+caffeine%2C+nicotine%2Bbitter+gourd%2C+nicotine%2B'tempeh'+and+nicotine%2Bcaffeine+induced+the+activities+of+liver+metabolizing+enzyme+significantly+compared+to+control.+At+low+doses%2C+bitter+gourd%2C+nicotine%2C+caffeine%2C+nicotine%2Bbitter+gourd%2C+nicotine%2B'tempeh'+and+nicotine%2Bcaffeine+induced+the+enzyme+but+'tempeh'+did+not.+Conclusion%3A+The+findings+suggest+that+bitter+gourd%2C+nicotine+and+caffeine+act+as+enzyme+inducers%2C+but+'tempeh'+only+demonstrate+this+ability+at+high+dose.&rft.date=2008&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F8255%2F1%2Fthe-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F8255%2F2%2Fthe-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html&rft.identifier=++Robson%2C+Noorzurani+and+Mustafa%2C+A.+M.++(2008)+The+effect+of+pretreatment+with+plant+extract%2C+nicotine+and+caffeine+on+sleeping+time+induced+by+pentobarbitone+in+mice.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F8255%2F<script src='//archive-bar.soton.ac.uk/archive-bar.js'></script>