TY  - GEN
ID  - cogprints8255
UR  - http://cogprints.org/8255/
A1  - Robson, Noorzurani
A1  - Mustafa, A. M.
TI  - The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice
Y1  - 2008///
N2  - Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose.
AV  - public
KW  - caffeine
KW  -  cytochrome
KW  -  enzyme
KW  -  extracts
KW  -  inducer
KW  -  liver
KW  -  metabolizing-enzyme
KW  -  nicotine
KW  -  p450
KW  -  plant
KW  -  
ER  -

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