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abstract: "Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose."
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creators_name:
- family: Robson
given: Noorzurani
honourific: ''
lineage: ''
- family: Mustafa
given: A. M.
honourific: ''
lineage: ''
date: 2008
date_type: published
datestamp: 2012-11-09 19:02:25
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dir: disk0/00/00/82/55
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eprint_status: archive
eprintid: 8255
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full_text_status: public
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keywords: 'caffeine, cytochrome, enzyme, extracts, inducer, liver, metabolizing-enzyme, nicotine, p450, plant, '
lastmod: 2012-11-09 19:02:25
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metadata_visibility: show
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number: 2
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pubdom: TRUE
publication: Internet Journal of Pharmacology
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refereed: TRUE
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reportno: ~
rev_number: 11
series: ~
source: ~
status_changed: 2012-05-13 12:50:06
subjects:
- soc-psy
succeeds: ~
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title: 'The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice'
type: journale
userid: 16139
volume: 5