%A Wonsang You %A J?rg Stadler %T Fractal-driven distortion of resting state functional networks in fMRI: a simulation study %X Fractals are self-similar and scale-invariant patterns found ubiquitously in nature. A lot of evidences implying fractal properties such as 1/f power spectrums have been also observed in resting state fMRI time series. While the traditional model of fractal behavior in resting state fMRI has been a fractional Gaussian noise, it is limited to describe the physical implication of fractal behavior on functional connectivity of the brain. To answer this problem, we have proposed the fractal-based model of resting state hemodynamic response function (rs-HRF) whose properties can be summarized by a fractal exponent. Here we show, through a simulation studies, that the fractal behavior of cerebral hemodynamics may cause significant distortion of network properties between neuronal activities and BOLD signals. We simulated neuronal population activities based on the stochastic neural field model from the Macaque brain network, and then obtained their corresponding BOLD signals by convolving them with the rs-HRF filter. The precision of centrality estimated in each node was deteriorated overall in three networks based on transfer entropy, mutual information, and Pearson correlation; particularly the distortion of transfer entropy was more sensitive to the standard deviation of fractal exponents. A node with high centrality was resilient to desynchronized fractal dynamics over all frequencies while a node with small centrality exhibited huge distortion of both wavelet correlation and centrality over low frequencies. This theoretical expectation indicates that the difference of fractal exponents between brain regions leads to discrepancy of statistical network properties, especially at nodes with small centrality, between neuronal activities and BOLD signals, and that the traditional definitions of resting state functional connectivity may not effectively reflect the dynamics of spontaneous neuronal activities. As an alternative, the nonfractal connectivity, which is defined as the correlation of nonfractal components of resting state BOLD signals, can be considered to overcome the fractal artifact. In conclusion, our simulation studies may give us insight into the influence of fractal behavior on complex networks of the brain. %D 2012 %K resting state, hemodynamic response, rs-HRF, functional connectivity, fMRI, fractal, long memory %L cogprints8468