creators_name: Agravat, AH creators_name: Dhruva, GA creators_name: Pujara, KM creators_name: Sanghvi, HK creators_id: dr.amit.patho@gmail.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2013-05-04 23:07:40 lastmod: 2013-05-04 23:07:40 metadata_visibility: show title: Role of Fine Needle Aspiration Cytology in Salivary Gland Pathology and its Histopathological Correlation: A Two Year Prospective Study in Western India. ispublished: pub subjects: OJHAS full_text_status: public keywords: Salivary gland tumours; FNAC; Diagnostic accuracy; Sensitivity; Specificity; Benign; Malignant abstract: Background and objectives: Salivary gland lesions account for 2-6.5% of all the neoplasms of the head and neck. Fine needle aspiration cytology (FNAC) is being increasingly used in the diagnosis of salivary gland lesions. The objective of this study was to evaluate the diagnostic accuracy and the sensitivity and specificity of FNAC in various salivary gland lesions in correlation with their histopathology, which helps in the appropriate therapeutic management. Methods: A total of 120 FNACs were done on salivary gland tumours from July 2010 to June 2012 in the Department of Pathology, P.D.U. Government Medical College, Rajkot (Gujarat, India). Formalin fixed (10%), surgically resected specimens were received, they were processed and slides were prepared for histopathological diagnosis. The stained cytological and histopathological slides were studied, analyzed and correlated. Results: The cytomorphological features were studied and analyzed and the following lesions were observed: Pleomorphic adenoma (88), Warthin’s tumour (2), Cystic lesion (4), Mucoepidermoid carcinoma (6), Acinic cell carcinoma (2), Primary lymphoma (2), Carcinoma EX pleomorphic adenoma(4), metastatic malignancy deposits (2), benign parotid tumour (8) and malignant tumour (unspecified)(2). A histopathological correlation was available in 78 cases. Out of these, 71 cases were true positive, 1 was false positive, 2 were false negative and 4 were true negative. Interpretation and conclusion: The overall sensitivity, specificity and the diagnostic accuracy were 97%, 80% and 92% respectively. Hence, the appropriate therapeutic management could be planned earlier. This study documents that FNAC of the salivary gland tumours is accurate, simple, rapid, inexpensive, well tolerated and harmless for the patient. date: 2012-10-25 date_type: published publication: Online Journal of Health and Allied Sciences volume: 11 number: 3(5) publisher: Kakkilaya BS refereed: TRUE referencetext: 1. Fernandes GC, Pandit AA. Diagnosis of salivary gland tumours by FNAC. Bombay Hospital Journal 2000;42:108-111. 2. Crystallini EG, Stafano A, Raffaelle F, Liberati F, Maccio T, Peciarolo A, et al. Fine needle aspiration biopsy of the salivary gland, 1985-1995. Acta Cytol 1997;41:1412-1420. 3. Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to the histological types, sites, age and sex distribution. J Pathol 1985;146:51-58. 4. Kline TS, Merriam JM, Shapshay SM. Aspiration biopsy cytology of the salivary gland. Am J Clin Pathol 1981;76:263-269. 5. Lindberg LG, Akerman M. 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