?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Chronic+Myeloid+Leukemia+with+Variant+Chromosomal+Translocations%3A+Results+of+Treatment+with+Imatinib+Mesylate.&rft.creator=Bhise%2C+R&rft.creator=Purohit%2C+S&rft.creator=Lokanatha%2C+D&rft.creator=Jacob%2C+L&rft.creator=Suresh%2C+TM&rft.creator=Govind+Babu%2C+K&rft.creator=Babu%2C+S&rft.creator=Lakshmaiah%2C+KC&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Objective%3A+To+evaluate+the+efficacy+of+imatinib+in+chronic+myeloid+leukemia+patients+with+variant+translocations.+Methods%3A+Forty+eight+chronic+myeloid+leukemia+patients+carrying+variant+translocations+and+treated+with+imatinib+at+our+institute+were+considered+for+the+study.+Survival+and+response+rates+were+evaluated.+Results%3A+The+median+follow+up+was+48+months(m).+Forty+three+(89.58%25)+patients+achieved+complete+hematologic+response.+Thirty+one+(64.58%25)+patients+achieved+complete+cytogenetic+response+and+19(39.58%25)+achieved+major+molecular+response+anytime+during+their+follow+up+period.+Only+18.75%25+of+the+patients+achieved+complete+cytogenetic+response+and+major+molecular+response+within+the+stipulated+time+frames.The+estimated+overall+survival+at+48+m+median+follow+up+was+81.2%25.The+progression+free+survival+was+also+81.2%25+and+the+event+free+survival+was+79.1%25.There+was+no+significant+survival+difference+between+low+vs+intermediate+and+high+risk+sokal+group.+Conclusion%3A+We+report+suboptimal+responses+to+imatinib+in+chronic+myeloid+leukemia+with+variant+translocations.+Further+studies+with+imatinib+and+the+newer+more+active+drugs+dasatinib+and+nilotinib+are+justified.&rft.publisher=Kakkilaya+BS&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2013-01-25&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F8934%2F1%2F2012-4-5.pdf&rft.identifier=++Bhise%2C+R+and+Purohit%2C+S+and+Lokanatha%2C+D+and+Jacob%2C+L+and+Suresh%2C+TM+and+Govind+Babu%2C+K+and+Babu%2C+S+and+Lakshmaiah%2C+KC++(2013)+Chronic+Myeloid+Leukemia+with+Variant+Chromosomal+Translocations%3A+Results+of+Treatment+with+Imatinib+Mesylate.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F8934%2F