title: Chronic Myeloid Leukemia with Variant Chromosomal Translocations: Results of Treatment with Imatinib Mesylate. creator: Bhise, R creator: Purohit, S creator: Lokanatha, D creator: Jacob, L creator: Suresh, TM creator: Govind Babu, K creator: Babu, S creator: Lakshmaiah, KC subject: Online Journal of Health and Allied Sciences description: Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations and treated with imatinib at our institute were considered for the study. Survival and response rates were evaluated. Results: The median follow up was 48 months(m). Forty three (89.58%) patients achieved complete hematologic response. Thirty one (64.58%) patients achieved complete cytogenetic response and 19(39.58%) achieved major molecular response anytime during their follow up period. Only 18.75% of the patients achieved complete cytogenetic response and major molecular response within the stipulated time frames.The estimated overall survival at 48 m median follow up was 81.2%.The progression free survival was also 81.2% and the event free survival was 79.1%.There was no significant survival difference between low vs intermediate and high risk sokal group. Conclusion: We report suboptimal responses to imatinib in chronic myeloid leukemia with variant translocations. Further studies with imatinib and the newer more active drugs dasatinib and nilotinib are justified. publisher: Kakkilaya BS contributor: Kakkilaya, Dr Srinivas date: 2013-01-25 type: Journal (On-line/Unpaginated) type: PeerReviewed format: application/pdf identifier: http://cogprints.org/8934/1/2012-4-5.pdf identifier: Bhise, R and Purohit, S and Lokanatha, D and Jacob, L and Suresh, TM and Govind Babu, K and Babu, S and Lakshmaiah, KC (2013) Chronic Myeloid Leukemia with Variant Chromosomal Translocations: Results of Treatment with Imatinib Mesylate. [Journal (On-line/Unpaginated)] relation: http://cogprints.org/8934/