---
abstract: "Cocaethylene is a psychoactive metabolite formed\r\nduring the combined consumption of cocaine and ethanol. As\r\nthis metabolite has many properties in common with cocaine, it is conceivable that cocaethylene administration may induce the activity of nuclear transcription factors that regulate the expression of late-response genes. Therefore, the temporal induction of FOS-like protein in rat brain was examined following IP administration of 60 mmol/kg cocaethylene. Immunoreactivity for the protein was detectable at 1 h in striatal neurons and had virtually disappeared 6 h after drug treatment. Administration of\r\nspecific dopaminergic (SCH-23390; 0.5 mg/kg) and glutamatergic (MK-801; 1 mg/kg) receptor antagonists prior to cocaethylene indicated a significant role for dopamine (D1) and Nmethyl-D-aspartate receptor subtypes in mediating the nuclear induction of the aforementioned transcription factor protein. In contrast, no significant effects on FOS-like protein in discrete neurons of the caudate putamen were found when spiradoline (U-62066), a kappa opioid-receptor agonist, was administered either IP (10 mg/kg) or directly (50 nmol) into the brain parenchyma. In addition, we uncovered a differential sensitivity of Long–Evans rats to the behavioral effects of cocaethylene, with the psychoactive metabolite producing significantly less behavioral activity (e.g., locomotion, rearing, and continuous sniffing)than that produced by cocaine (molar equivalent of 60 mmol/kg cocaethylene). These findings indicate both common and disparate effects of cocaethylene and its parent compound, cocaine, on receptor pathways that regulate target alterations in gene expression and drug-induced motor behavior."
altloc: []
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
  - ~
  - ~
  - kristal@buffalo.edu
  - ~
creators_name:
  - family: Horowitz
    given: J.M.
    honourific: Dr.
    lineage: ''
  - family: DiPirro
    given: J.M.
    honourific: Dr.
    lineage: ''
  - family: Kristal
    given: M.B.
    honourific: Dr.
    lineage: ''
  - family: Torres
    given: G.
    honourific: Dr.
    lineage: ''
date: 1997
date_type: published
datestamp: 2013-05-04 23:21:37
department: ~
dir: disk0/00/00/89/52
edit_lock_since: ~
edit_lock_until: 0
edit_lock_user: ~
editors_id: []
editors_name: []
eprint_status: archive
eprintid: 8952
fileinfo: /style/images/fileicons/application_pdf.png;/8952/1/Brain%20Res%20Bull.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: ~
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'cocaine, alcohol, cocaethylene, fos'
lastmod: 2013-05-04 23:21:37
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 5
pagerange: 393-398
pubdom: TRUE
publication: Brain Research Bulletin
publisher: Elsevier
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 11
series: ~
source: ~
status_changed: 2013-05-04 23:21:37
subjects:
  - behav-neuro-sci
  - neuro-chem
  - neuro-pharm
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Dopaminergic, glutamatergic but not opioidergic mechanisms mediate induction of FOS-like protein by cocaethylene'
type: journalp
userid: 88
volume: 42
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