?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Adolescent+Neuroblastoma+of+Lower+Limb&rft.creator=Rajeshwari%2C+K&rft.creator=Dravid%2C+NV&rft.creator=Goyal%2C+N&rft.creator=Gadri%2C+A&rft.creator=Pawar%2C+S&rft.creator=Karibasappa%2C+GN&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Neuroblastoma+is+an+embryonic+tumour+of+neural+crest+origin%2C+commonly+seen+in+children+with+upper+abdomen+involvement.+Rarely+neuroblastomas+present+in+adolescents+and+adults+involving+lower+limb.+Histopathologically+neuroblastoma+of+lower+limb+can+be+confused+with+other+small+round+cell+tumour+especially+with+Ewing%E2%80%99s+sarcoma+and+rhabdomyosarcoma.+A+16+year+old+male+presented+with+15x11cm+swelling%2C+pain+and+multiple+discharging+sinuses+of+right+leg+since+4+months.+Routine+haematological+and+biochemical+analysis+were+within+normal+limits.+Radiology+of+right+leg+showed+large+soft+tissue+swelling+encompassing+the+pathological+fracture+of+tibia+and+bowing+of+fibula.+Fine+needle+aspiration+of+the+swelling+revealed+malignant+small+round+cell+tumour.+Histopathology+revealed+poorly+differentiated+neuroblastoma+of+lower+limb.+The+immunohistochemistry+of+Synaptophysin+and+Chromogranin+were+positive+and+CD+99+was+negative.+Neuroblastoma+diagnosed+at+unusual+site+with+uncommon+age+has+poor+prognosis.+Hence%2C+one+must+keep+in+mind+the+differential+diagnosis+of+neuroblastoma+as+one+of+the+differential+diagnosis+in+evaluating+the+soft+tissue+tumours+of+lower+limb.&rft.publisher=Kakkilaya+BS&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2013-04-15&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F9143%2F1%2F2013-1-9.pdf&rft.identifier=++Rajeshwari%2C+K+and+Dravid%2C+NV+and+Goyal%2C+N+and+Gadri%2C+A+and+Pawar%2C+S+and+Karibasappa%2C+GN++(2013)+Adolescent+Neuroblastoma+of+Lower+Limb.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F9143%2F