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abstract: 'Renal cell carcinoma is the most common neoplasm of the kidney comprised of different histological variants. Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC) mainly diagnosed in the sixth decade of life. It is important to identify this entity because it has significantly better prognosis than the clear cell (conventional) and papillary renal cell carcinomas. The chromophobe renal cell carcinoma should be differentiated from oncocytoma and clear cell carcinoma. We report a case of a 70 year-old male who presented with a six month history of hematuria, left sided flank pain and a palpable non-tender lump in the left lumbar region. On radiology, the possibility of a left renal neoplasm was raised. A left radical nephrectomy was done and histopathological diagnosis of Type 2 (mixed) chromophobe renal cell carcinoma was given. We present this case owing to its relative rarity of incidence, difficulties encountered and differential diagnoses to be considered during diagnosis as the prognosis and management protocols differ with different variants.'
altloc:
  - http://www.ojhas.org/issue45/2013-1-15.html
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contact_email: ~
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  - khatibwasim@gmail.com
creators_name:
  - family: Wader
    given: JV
    honourific: ''
    lineage: ''
  - family: Kumbhar
    given: SS
    honourific: ''
    lineage: ''
  - family: Huddedar
    given: AD
    honourific: ''
    lineage: ''
  - family: Khatib
    given: WGM
    honourific: ''
    lineage: ''
date: 2013-04-15
date_type: published
datestamp: 2014-02-25 12:41:20
department: ~
dir: disk0/00/00/91/48
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editors_id:
  - Kakkilaya BS
editors_name:
  - family: Kakkilaya
    given: Srinivas
    honourific: Dr
    lineage: ''
eprint_status: archive
eprintid: 9148
fileinfo: /style/images/fileicons/application_pdf.png;/9148/1/2013-1-15.pdf
full_text_status: public
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keywords: Chromophobe renal cell carcinoma; Type 2 mixed variant
lastmod: 2014-02-25 12:41:20
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 1(15)
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pubdom: TRUE
publication: Online Journal of Health and Allied Sciences
publisher: Kakkilaya BS
refereed: TRUE
referencetext: "1.\tFerlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010:15;2893-2917.\r\n2.\tLjungberg B et al. The Epidemiology of Renal Cell Carcinoma. Eur Urol. Oct 2011;60(4):29-36.\r\n3.\tOrdonez NG, Rosai J. Urinary Tract: Kidney, Renal pelvis and Ureter; Bladder. In: Rosai and Ackerman’s Surgical Pathology. 10th ed. Vol(2). Mosby Elsevier. 2011. pp 1183-1193.\r\n4.\tCrotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: Clinicopathological features of 50 cases. J Urol. 1995;154:964-967.\r\n5.\tEble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and Genetics of the tumors of the urinary system and male genital organs. WHO classification of Tumours. IARC Press; Lyon, France. 2004.\r\n6.\tThoenes W, Storkel S, Rumpelt MJ. Human chromophobe cell renal carcinoma. Virchows Arch Cell Pathol. 1985;48:207–217.\r\n7.\tStec R, Grala B, Maczewski M, Bodnar L, Szczylik C. Chromophobe renal cell cancer - review of the literature and potential methods of treating metastatic disease. J Exp Clin Cancer Res. 2009;28(1):134.\r\n8.\tAlpers CE. The Kidney. In: Kumar V, Abbas A, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic basis of disease. 8th ed. Saunders Elsevier. 2010. pp 963-967.\r\n9.\tCheville JC, Lohse CM, Zincke H, Weaver H, Blute AL, Michael L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27:612-624.\r\n10.\tVera-Badillo FE, Conde E, Duran I. Chromophobe renal cell carcinoma: A review of an uncommon entity. Int J Urol. May 2012:1-7.\r\n11.\tAkhthar M, Kardar H, Linjawi T, McClintock J, Ali MA. Chromophobe cell carcinoma of the kidney: A clinicopathologic study of 21 cases. Am J Surg Pathol  1995;19:1245–1256.\r\n12.\tOnishi T, Oishi Y, Yauda S, Abe K, Hasegawa T, Maeda S. Prognostic implications of histological features in patients with chromophobe RCC. BJU Int. 2002;90:529–532."
relation_type: []
relation_uri: []
reportno: ~
rev_number: 8
series: ~
source: ~
status_changed: 2014-02-25 12:41:20
subjects:
  - OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Chromophobe Renal Cell Carcinoma
type: journale
userid: 4338
volume: 12
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